Gfeller W, Kobel W, Seifert G
Food Chem Toxicol. 1985 Feb;23(2):165-8. doi: 10.1016/0278-6915(85)90009-2.
Determining the irritant effects of chemicals in experimental animals provides the public with information on and protection against possible hazards that may arise from exposure of the human skin. Furthermore, the data obtained are used for registration and classification purposes. This paper reviews the methods proposed in the most important guidelines (OECD, EEC and FIFRA guidelines) and points out the critical experimental points. It shows that the introduction of OECD Guideline No. 404 can lead to a reduction in the number of test animals used for skin irritation testing.
确定化学物质对实验动物的刺激作用，可为公众提供有关人体皮肤接触可能产生的潜在危害的信息并提供防护。此外，所获得的数据用于注册和分类目的。本文回顾了最重要指南（经合组织、欧共体和美国联邦法规指南）中提出的方法，并指出了关键实验要点。结果表明，采用经合组织第404号指南可减少用于皮肤刺激试验的实验动物数量。
