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工业化学品眼部刺激评分分布

Distribution of eye irritation scores of industrial chemicals.

作者信息

Kobel W, Gfeller W

出版信息

Food Chem Toxicol. 1985 Feb;23(2):311-2. doi: 10.1016/0278-6915(85)90036-5.

DOI:10.1016/0278-6915(85)90036-5
PMID:4040082
Abstract

Eye irritation results obtained in tests on agricultural and industrial chemicals (raw materials, intermediates, formulation components and sales products) were classified on the basis of an arbitrary breakdown of the scores (which ranged from 0 (no irritation) to a maximum of 110) into six categories. This showed that of the materials (about 600) tested over a 2-year period, 18-31% caused no irritation at all, 42-51% caused minimal irritation (scores of 0.1-10.9), 9-17% were classed as slightly irritant (11.0-25.9) and 8-12% as moderately irritant (26.0-55.9), while 2-6 and 1-5% came into the categories of strong and extreme irritants, respectively (with scores of 56.0-84.0 and 84.1-110). Testing of the last two groups involves the test animals in discomfort, but because of the seriousness of eye damage to man this cannot always be avoided.

摘要

对农用和工业化学品(原材料、中间体、配方成分及销售产品)进行的眼刺激试验结果,是根据对分数(范围从0(无刺激)到最高110)的任意划分归为六类的。结果显示,在两年时间内测试的约600种物质中,18 - 31%根本不会引起刺激,42 - 51%引起最小刺激(分数为0.1 - 10.9),9 - 17%被归类为轻度刺激(11.0 - 25.9),8 - 12%为中度刺激(26.0 - 55.9),而分别有2 - 6%和1 - 5%属于强刺激和极刺激类别(分数为56.0 - 84.0和84.1 - 110)。对最后两组的测试会使实验动物不适,但由于对人类眼睛损害的严重性,这种情况有时无法避免。

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