氟化硝基苯对多形核白细胞功能的抑制作用。

Inhibition of polymorphonuclear leukocyte functions by fluorinated nitrobenzenes.

作者信息

Elferink J G, Deierkauf M

出版信息

Chem Biol Interact. 1984 Dec;52(2):163-72. doi: 10.1016/0009-2797(84)90070-x.

Abstract

The bifunctional fluorinated nitrobenzenes, 1,5-difluoro-2,4-dinitrobenzene (DFDNB) and 4,4'-difluoro-3,3'-dinitrodiphenyl sulfone (DFDNDPS), and the monofunctional 1-fluoro-2,4-dinitrobenzene (FDNB) inhibit chemotaxis, phagocytosis, exocytosis and the respiratory burst of rabbit polymorphonuclear leukocytes. Inhibition occurs in the micromolar concentration range; the bifunctional compounds are stronger inhibitory than the monofunctional one. The inhibitory effect can be counteracted by sulfhydryl compounds and not with amino-group containing compounds. The results suggest that an interaction with vulnerable sulfhydryl groups, located in a hydrophobic surrounding, is the basis of the inhibitory effect of the fluorinated nitrobenzenes.

摘要

双功能氟化硝基苯1,5 - 二氟 - 2,4 - 二硝基苯（DFDNB）和4,4'- 二氟 - 3,3'- 二硝基二苯砜（DFDNDPS），以及单功能的1 - 氟 - 2,4 - 二硝基苯（FDNB）可抑制兔多形核白细胞的趋化作用、吞噬作用、胞吐作用和呼吸爆发。抑制作用发生在微摩尔浓度范围内；双功能化合物的抑制作用比单功能化合物更强。巯基化合物可抵消这种抑制作用，而含氨基的化合物则不能。结果表明，与位于疏水环境中的易损巯基相互作用是氟化硝基苯抑制作用的基础。