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用新生霉素、四环素和利福平处理的K-12 MG1655的转录组测序数据集。

Transcriptome sequencing data sets of K-12 MG1655 treated with novobiocin, tetracycline, and rifampicin.

作者信息

Balkin Alexander, Plotnikov Andrey, Konnova Tatiana, Shagimardanova Elena, Hamo Hamza, Gogolev Yuri, Gogoleva Natalia

机构信息

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.

Institute for Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, Orenburg, Russia.

出版信息

Microbiol Resour Announc. 2025 Jun 12;14(6):e0116924. doi: 10.1128/mra.01169-24. Epub 2025 May 22.

DOI:10.1128/mra.01169-24
PMID:40401950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12160492/
Abstract

This report presents transcriptome datasets for MG1655 treated with novobiocin, rifampicin, and tetracycline. Clusters of genes that respond to inhibition of RNA synthesis, protein synthesis, and DNA gyrase activity have been identified. The data may help to understand the mechanisms of general and specific resistance in .

摘要

本报告展示了用新生霉素、利福平及四环素处理的MG1655的转录组数据集。已鉴定出对RNA合成抑制、蛋白质合成抑制及DNA促旋酶活性抑制有反应的基因簇。这些数据可能有助于理解……中普遍和特异性抗性的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b8/12160492/5036d83912cf/mra.01169-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b8/12160492/5036d83912cf/mra.01169-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b8/12160492/5036d83912cf/mra.01169-24.f001.jpg

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2
A comparative study on the genomes, transcriptomes, and metabolic properties of strains Nissle 1917, BL21(DE3), and MG1655.对Nissle 1917、BL21(DE3)和MG1655菌株的基因组、转录组和代谢特性的比较研究。
Eng Microbiol. 2022 Feb 21;2(1):100012. doi: 10.1016/j.engmic.2022.100012. eCollection 2022 Mar.
3
Comparative Analysis of Transcriptomic Response of Escherichia coli K-12 MG1655 to Nine Representative Classes of Antibiotics.
大肠杆菌K-12 MG1655对九种代表性抗生素类别的转录组反应的比较分析
Microbiol Spectr. 2023 Feb 28;11(2):e0031723. doi: 10.1128/spectrum.00317-23.
4
Twelve years of SAMtools and BCFtools.SAMtools 和 BCFtools 十二年。
Gigascience. 2021 Feb 16;10(2). doi: 10.1093/gigascience/giab008.
5
Transcriptomic data of subsp. serovar Typhimurium str. 14028S treated with novobiocin.用新生霉素处理的鼠伤寒沙门氏菌亚种血清型鼠伤寒菌株14028S的转录组数据。
Data Brief. 2020 Feb 17;29:105297. doi: 10.1016/j.dib.2020.105297. eCollection 2020 Apr.
6
iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data.iDEP：一个用于 RNA-Seq 数据差异表达和通路分析的集成网络应用程序。
BMC Bioinformatics. 2018 Dec 19;19(1):534. doi: 10.1186/s12859-018-2486-6.
7
Salmon provides fast and bias-aware quantification of transcript expression.鲑鱼提供快速且无偏倚的转录本表达定量。
Nat Methods. 2017 Apr;14(4):417-419. doi: 10.1038/nmeth.4197. Epub 2017 Mar 6.
8
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