Adongo Donatus Wewura, Adedia David, Tandoh Augustine, Amekyeh Hilda, Asosega Killian Asampana, Benneh Charles Kwaku, Lawluvi Eli Yao, Ben Inemesit Okon, Hohoayi Abigail, Wiafe Ebenezer, Ofori-Amoah Jones, Nanga Salifu, Woode Eric
Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Department of Basic Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
PLoS One. 2025 May 22;20(5):e0323793. doi: 10.1371/journal.pone.0323793. eCollection 2025.
Food-drug interactions (FDIs) are a significant clinical concern, impacting the effectiveness and safety of treatments. Healthcare professionals (HCPs) play a crucial role in minimizing these risks through appropriate patient education. The Ho Teaching Hospital (HTH) in Ghana serves a large patient population with varying medication needs. However, there is limited data on the knowledge and attitudes of HCPs regarding FDIs in this setting.
This study assessed and modelled the knowledge and attitudes of HCPs towards FDIs at HTH.
A cross-sectional survey of 300 HCPs, including medical doctors, pharmacists, nurses, midwives, and dietitians, was conducted using a self-administered questionnaire. Data were analyzed using Kruskal-Wallis tests, logistic regression models and path analysis.
The mean knowledge score on FDIs was 27.52 (SD = 8.71) out of 61, indicating low knowledge. Pharmacists scored the highest, while profession and sex significantly influenced knowledge levels (p < 0.05). Only 39% of participants demonstrated high knowledge, and 49.70% exhibited a good attitude towards FDIs. Males were less likely to show good attitudes compared to females (aOR = 0.15; p = 0.038). HCPs who attended FDI training (aOR = 1.83; p = 0.027) and Christians (aOR = 2.17; p = 0.048) displayed more favorable attitudes. The mediation analysis revealed that knowledge of alcohol-drug interactions influences overall attitudes through pathways involving knowledge of drug-food time intervals.
Knowledge of FDIs among HCPs is inadequate, with significant variability across professions. Pharmacists demonstrated the highest knowledge levels, while overall attitudes varied by sex, training, and religious affiliation. These findings highlight the need for targeted educational programs and training for HCPs regarding FDIs.
食物-药物相互作用（FDIs）是一个重大的临床问题，会影响治疗的有效性和安全性。医疗保健专业人员（HCPs）通过适当的患者教育在将这些风险降至最低方面发挥着关键作用。加纳的霍教学医院（HTH）为大量有不同药物需求的患者提供服务。然而，在这种情况下，关于HCPs对FDIs的知识和态度的数据有限。
本研究评估并模拟了HTH的HCPs对FDIs的知识和态度。
使用自填式问卷对300名HCPs进行了横断面调查，这些人员包括医生、药剂师、护士、助产士和营养师。使用Kruskal-Wallis检验、逻辑回归模型和路径分析对数据进行了分析。
在满分61分的FDIs知识测试中，平均得分是27.52（标准差=8.71），表明知识水平较低。药剂师得分最高，而职业和性别对知识水平有显著影响（p<0.05）。只有39%的参与者表现出高知识水平，49.70%的参与者对FDIs表现出良好态度。与女性相比，男性表现出良好态度的可能性较小（调整后比值比=0.15；p=0.038）。参加过FDIs培训的HCPs（调整后比值比=1.83；p=0.027）和基督教徒（调整后比值比=2.17；p=0.048）表现出更积极的态度。中介分析表明，酒精-药物相互作用的知识通过涉及药物-食物时间间隔知识的途径影响总体态度。
HCPs对FDIs的知识不足，各职业之间存在显著差异。药剂师表现出最高的知识水平，而总体态度因性别、培训和宗教信仰而异。这些发现凸显了针对HCPs开展关于FDIs的针对性教育项目和培训的必要性。
