Qaisar Rizwan, Hussain M Azhar, Franzese Fabio, Karim Asima, Ahmad Firdos, Awad Atif, Alsaeed Mohammed, Alkahtani Shaea Ayed
Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Space Medicine Research Group, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Sci Rep. 2025 May 22;15(1):17833. doi: 10.1038/s41598-025-03128-y.
Muscle weakness is a risk factor for multiple diseases. However, most protocols to assess muscle weakness require clinical settings. A difficulty lifting 5 kg may be a simple measure of muscle weakness in domestic settings. However, no relevant study on assessing muscle weakness has been reported. We investigated the associations of difficulty lifting 5 kg with various musculoskeletal, cardiovascular, metabolic, and neurological diseases in geriatric adults aged 50 or above from 15 countries (n = 51,536) over five years. The data was collected by the Survey of Health, Ageing, and Retirement in Europe (SHARE) conducted between 2013 and 2020. Overall, 10,025 (19.5%) respondents exhibited difficulty lifting 5 kg at baseline in 2013. Over the next four years, these respondents exhibited higher risks for developing a low quality of life (QoL) (9.42%), depression (8.14%), low handgrip strength (7.38%), and osteoarthritis (6.98%) after adjusting for age and gender. Additionally, these respondents exhibited mild to moderate risks for developing rheumatoid arthritis, heart attack, diabetes mellitus, hypertension, Alzheimer's disease, stroke, or hip fracture (all p < 0.05). After adjusting for age and country, the risks of developing various diseases were higher in men than in women. Collectively, difficulty lifting 5 kg can herald the onset of several cardiovascular, neurological, and musculoskeletal disorders along with a reduced QoL. We suggest that difficulty lifting 5 kg may be a valuable indicator of muscle weakness and poor health in domestic settings.
肌肉无力是多种疾病的危险因素。然而，大多数评估肌肉无力的方案都需要临床环境。在家中，难以举起5公斤重物可能是肌肉无力的一个简单衡量指标。然而，尚未有关于评估肌肉无力的相关研究报道。我们调查了来自15个国家的50岁及以上老年成年人（n = 51536）在五年内难以举起5公斤重物与各种肌肉骨骼、心血管、代谢和神经系统疾病之间的关联。数据是通过2013年至2020年期间进行的欧洲健康、老龄化和退休调查（SHARE）收集的。总体而言，在2013年基线时，10025名（19.5%）受访者表现出难以举起5公斤重物。在接下来的四年里，在调整年龄和性别后，这些受访者出现生活质量低下（9.42%）、抑郁（8.14%）、握力低下（7.38%）和骨关节炎（6.98%）的风险更高。此外，这些受访者患类风湿性关节炎、心脏病发作、糖尿病、高血压、阿尔茨海默病、中风或髋部骨折的风险为轻度至中度（所有p < 0.05）。在调整年龄和国家后，男性患各种疾病的风险高于女性。总体而言，难以举起5公斤重物可能预示着几种心血管、神经和肌肉骨骼疾病的发作以及生活质量的下降。我们认为，难以举起5公斤重物可能是家庭环境中肌肉无力和健康状况不佳的一个有价值指标。
