Johansson U, Akesson B
Int J Vitam Nutr Res. 1985;55(2):197-204.
Healthy adults were given four diets, each one for one week: Low ascorbic acid diet, low ascorbic acid diet plus acetylsalicylic acid (3 g/d), high ascorbic acid diet (1 g/d) and high ascorbic acid diet plus acetylsalicylic acid. At low ascorbic acid intake, acetylsalicylic acid increased urinary ascorbic acid, but at high ascorbic acid intake, acetylsalicylic acid instead decreased urinary ascorbic acid. The latter effect was probably due to an inhibited intestinal absorbtion of ascorbic acid, and the former effect may reflect decreased protein binding and tissue uptake of ascorbic acid caused by acetylsalicylic acid. In no instance, acetylsalicylic acid affected plasma ascorbic acid. The effect of ascorbic acid on substances related to lipid peroxidation was investigated. The high ascorbic acid diets decreased plasma lipoperoxide and retinol binding protein. No change was observed in serum tocopherol, iron status, erythrocyte lipid fluorescence, plasma ceruloplasmin, urinary and plasma selenium and glutathione peroxidase activity. Thus, one-week supplementation of ascorbic acid seems to have only marginal effects on lipid peroxidation and antioxidant status.
健康成年人被给予四种饮食，每种饮食持续一周：低抗坏血酸饮食、低抗坏血酸饮食加乙酰水杨酸（3克/天）、高抗坏血酸饮食（1克/天）以及高抗坏血酸饮食加乙酰水杨酸。在低抗坏血酸摄入量时，乙酰水杨酸会增加尿抗坏血酸，但在高抗坏血酸摄入量时，乙酰水杨酸反而会降低尿抗坏血酸。后一种效应可能是由于抗坏血酸的肠道吸收受到抑制，而前一种效应可能反映了乙酰水杨酸导致的抗坏血酸蛋白结合减少和组织摄取减少。在任何情况下，乙酰水杨酸都不会影响血浆抗坏血酸。研究了抗坏血酸对与脂质过氧化相关物质的影响。高抗坏血酸饮食降低了血浆脂质过氧化物和视黄醇结合蛋白。血清生育酚、铁状态、红细胞脂质荧光、血浆铜蓝蛋白、尿和血浆硒以及谷胱甘肽过氧化物酶活性均未观察到变化。因此，为期一周的抗坏血酸补充似乎对脂质过氧化和抗氧化状态只有轻微影响。
