Li ChunMei, Xu Jing
Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, China.
Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, China.
Diabetol Metab Syndr. 2024 May 23;16(1):113. doi: 10.1186/s13098-024-01353-5.
Insulin resistance (IR) is strongly correlated with the decreased deficiency of testosterone levels in males. The metabolic score for insulin resistance (METS-IR) index is regarded as an innovative measure for the assessment on IR. The research aims to explore the correlation between the METS-IR index and the testosterone levels in males.
In this study, a cross-sectional design was made through the data obtained from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Besides, the METS-IR index was derived from serum triglyceride levels, fasting plasma glucose, HDL-C and BMI.
A total of 2082 participants were included in the final analysis. After controlling for confounding variables, it was found that METS-IR was independently and negatively correlated with testosterone levels (β = -3.88, 95% CI = -4.49, -3.27, P < 0.001). As shown by the generalized smooth curve fitting, METS-IR had a linear correlation with testosterone levels without threshold or saturation effects, which was consistently observed across all subgroups through stratified analysis (all P > 0.05). As revealed by the analysis on the ROC curve, the area under the curve (AUC) for the METS-IR index (0.732, 95% CI = 0.705, 0.760) was significantly larger than that of homeostatic model assessment of insulin resistance (HOMA-IR), TG/HDL ratio, triglyceride-glucose index (TyG) and body mass index (BMI).
The findings suggest a negative relationship between the METS-IR index and the testosterone levels in male adults. Furthermore, the METS-IR index demonstrates superior predictive ability for testosterone deficiency in comparison to HOMA-IR, TG/HDL ratio, TyG and BMI.
胰岛素抵抗（IR）与男性睾酮水平降低密切相关。胰岛素抵抗代谢评分（METS-IR）指数被视为评估IR的一种创新指标。本研究旨在探讨METS-IR指数与男性睾酮水平之间的相关性。
本研究采用横断面设计，数据来源于2013年至2020年的美国国家健康与营养检查调查（NHANES）。此外，METS-IR指数由血清甘油三酯水平、空腹血糖、高密度脂蛋白胆固醇（HDL-C）和体重指数（BMI）得出。
最终分析纳入了2082名参与者。在控制混杂变量后，发现METS-IR与睾酮水平呈独立负相关（β = -3.88，95%置信区间[CI] = -4.49，-3.27，P < 0.001）。广义平滑曲线拟合显示，METS-IR与睾酮水平呈线性相关，无阈值或饱和效应，分层分析在所有亚组中均一致观察到这一结果（所有P > 0.05）。ROC曲线分析显示，METS-IR指数的曲线下面积（AUC）为0.732（95%CI = 0.705，0.760），显著大于胰岛素抵抗稳态模型评估（HOMA-IR）、甘油三酯/高密度脂蛋白比值、甘油三酯-葡萄糖指数（TyG）和体重指数（BMI）。
研究结果表明，METS-IR指数与成年男性的睾酮水平呈负相关。此外，与HOMA-IR、甘油三酯/高密度脂蛋白比值、TyG和BMI相比，METS-IR指数对睾酮缺乏具有更强的预测能力。
