Aabedi Andre, Fraix Marcel P, Agrawal Devendra K
Departments of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Physical Medicine and Rehabilitation, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
J Orthop Sports Med. 2025;7(1):169-178. doi: 10.26502/josm.511500192. Epub 2025 Mar 31.
Severe osteoarthritis (OA) is a debilitating condition that often necessitates surgical intervention when conservative treatments fail. We carefully reviewed the literature on the pros and cons of surgical options for severe OA, focusing on total joint arthroplasty (TJA) and other surgical techniques. Total joint arthroplasty, including total knee arthroplasty (TKA) and total hip arthroplasty (THA), is the most established surgical option for severe OA, providing significant pain relief, functional restoration, and improved quality of life. The American College of Rheumatology and the American Association of Hip and Knee Surgeons recommend proceeding to TJA without delay in patients with symptomatic moderate-to-severe OA unresponsive to nonoperative therapy. Osteotomies and cartilage repair procedures are less commonly performed and have limited evidence supporting their long-term efficacy in reducing OA progression. Arthroscopic interventions, such as lavage and debridement, do not alter disease progression and are not recommended for routine treatment of OA. While TJA is highly effective, it is associated with risks such as postoperative complications, revisions, and reoperations. The cost-effectiveness of TJA is well-documented, making it a favorable option for managing end stage OA. However, patient selection is crucial, and factors such as age, comorbidities, and obesity must be considered to optimize outcomes. Total joint arthroplasty remains the gold standard for surgical management of severe OA, offering substantial benefits in pain relief and functional improvement. Other surgical options, such as osteotomies and arthroscopy, have limited roles and should be considered based on individual patient factors and disease severity. Evidence-based guidelines support the timely use of TJA to enhance patient outcomes and quality of life.
重度骨关节炎(OA)是一种使人衰弱的病症,保守治疗失败时通常需要手术干预。我们仔细回顾了关于重度OA手术选择利弊的文献,重点关注全关节置换术(TJA)和其他手术技术。全关节置换术,包括全膝关节置换术(TKA)和全髋关节置换术(THA),是重度OA最成熟的手术选择,能显著缓解疼痛、恢复功能并改善生活质量。美国风湿病学会和美国髋膝关节外科医师协会建议,对非手术治疗无反应的有症状中重度OA患者应立即进行TJA。截骨术和软骨修复手术较少进行,且支持其在减缓OA进展方面长期疗效的证据有限。关节镜干预,如灌洗和清创,不会改变疾病进展,不建议用于OA的常规治疗。虽然TJA非常有效,但它存在术后并发症、翻修和再次手术等风险。TJA的成本效益有充分记录,使其成为治疗终末期OA的有利选择。然而,患者选择至关重要,必须考虑年龄、合并症和肥胖等因素以优化治疗效果。全关节置换术仍然是重度OA手术治疗的金标准,在缓解疼痛和改善功能方面有显著益处。其他手术选择,如截骨术和关节镜检查,作用有限,应根据个体患者因素和疾病严重程度来考虑。基于证据的指南支持及时使用TJA以提高患者治疗效果和生活质量。