Suwan Natthima, Jenjittikul Sirinya, Tiratrakoonseree Rattichid, Jiradanaipat Chanyapat, Teerawongsuwan Sasipat, Phathomrapeepong Wipawadee, Phanwanich Warangkhana, Rungsiwiwut Ruttachuk
Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
Vet Med (Praha). 2025 Apr 28;70(4):143-149. doi: 10.17221/93/2024-VETMED. eCollection 2025 Apr.
Management of chronic non-healing wounds in cats requires a comprehensive approach. This report describes the treatment of a severe open skin wound on the skull using a combined approach involving allogeneic adipose-derived mesenchymal stem cells (MSCs) and autologous platelet-rich plasma (PRP). A 12-year-old neutered male mixed-breed domestic cat presented with a non-healing chronic wound on the skull. The wound extended from the orbital to the occipital area and from the left to the right temporal region. Laboratory test results were positive for feline immunodeficiency virus and impaired kidney function. Sensitivity tests revealed resistance to several antibiotics. Due to limited skin reconstruction options, MSCs were administered subcutaneously at the wound edge once a month for three months. PRP was collected one month after the initial MSC administration and injected at the wound edge monthly between MSC treatments. The wound diameter was measured daily during saline cleaning. The cat received protein-supplemented food daily. Wound healing was observed two weeks after the MSC administration, gradually decreasing in size and closing completely within 5 months. This case demonstrates the successful application of MSCs and PRP for treating chronic wounds in cats.
猫慢性难愈合伤口的管理需要综合方法。本报告描述了使用同种异体脂肪间充质干细胞（MSC）和自体富血小板血浆（PRP）的联合方法治疗一只猫颅骨上严重的开放性皮肤伤口。一只12岁已绝育的雄性混种家猫出现颅骨上的慢性难愈合伤口。伤口从眼眶延伸至枕部区域，从左侧颞部延伸至右侧颞部区域。实验室检测结果显示猫免疫缺陷病毒呈阳性且肾功能受损。药敏试验显示对几种抗生素耐药。由于皮肤重建选择有限，在三个月内每月一次在伤口边缘皮下注射MSC。在首次注射MSC后一个月采集PRP，并在两次MSC治疗之间每月在伤口边缘注射。在生理盐水清洗期间每天测量伤口直径。这只猫每天接受补充蛋白质的食物。在注射MSC两周后观察到伤口愈合，伤口大小逐渐减小并在5个月内完全闭合。该病例证明了MSC和PRP在治疗猫慢性伤口方面的成功应用。
