Rossi Carlo Maria, Lenti Marco Vincenzo, Merli Stefania, Fiorita Martina, Lo Bello Antonio, Latorre Mario Andrea, Bianchi Paola Ilaria, Aronico Nicola, De Silvestri Annalisa, Di Sabatino Antonio
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Front Allergy. 2025 May 8;6:1568595. doi: 10.3389/falgy.2025.1568595. eCollection 2025.
Pollen allergy may influence irritable bowel syndrome (IBS) symptoms; however, available data are scant.
This study aims to assess symptom variability in atopic IBS patients.
We retrospectively analysed consecutive adult IBS patients evaluated between 2021 and 2024. Patients from the overall IBS cohort and the IBS-diarrhoea (IBS-D) subgroup were classified according to their sensitisation into grass-positive, house dust mite (HDM)-positive, or unsensitised. Symptom burden was assessed using the gastrointestinal symptom rating scale (GSRS) and a visual analogue scale for abdominal pain/distension, both outside the season period (T0) and during the pollination season (T1).
A total of 61 IBS patients were recruited (median age 34 years, IQR 25-50, F:M ratio 3.6:1), including 38 patients (62.8%) with IBS-D (median age 30 years, IQR 28-47, F:M ratio 2.8:1). Atopy was common in the IBS-D subgroup, particularly with respiratory manifestations. The mean GSRS significantly ( < 0.01) increased at T1 (variance of 3.4 points) only in grass-sensitised patients as opposed to those sensitised to HDM or unsensitised ones; this effect was present only in the IBS-D subgroup, while no significant variation was observed in the overall cohort.
Pollination season influences symptoms in IBS-D patients sensitised to seasonal allergens.
花粉过敏可能会影响肠易激综合征（IBS）的症状；然而，现有数据很少。
本研究旨在评估特应性IBS患者的症状变异性。
我们回顾性分析了2021年至2024年间连续评估的成年IBS患者。将整个IBS队列和IBS腹泻（IBS-D）亚组中的患者根据其致敏情况分为草花粉阳性、屋尘螨（HDM）阳性或未致敏。在非花粉季节（T0）和授粉季节（T1）期间，使用胃肠道症状评定量表（GSRS）和腹痛/腹胀视觉模拟量表评估症状负担。
共招募了61名IBS患者（中位年龄34岁，IQR 25-50，女性与男性比例为3.6:1），其中包括38名（62.8%）IBS-D患者（中位年龄30岁，IQR 28-47，女性与男性比例为2.8:1）。特应性在IBS-D亚组中很常见，尤其是伴有呼吸道表现。仅在对草花粉致敏的患者中，T1时的平均GSRS显著升高（<0.01）（方差为3.4分），而对HDM致敏或未致敏的患者则不然；这种效应仅在IBS-D亚组中存在，而在整个队列中未观察到显著变化。
授粉季节会影响对季节性过敏原致敏的IBS-D患者的症状。
