Haye-Bertolozzi Joanna E, DeFreece Cecily B, Bolden Christopher, Daveron Kalila, Biliran Hector
Xavier University of Louisiana, Department of Biology, New Orleans, Louisiana, USA.
Department of Molecular and Environmental Toxicology, University of Wisconsin Madison, Madison, Wisconsin, USA.
Biochem Mol Biol Educ. 2025 May 23. doi: 10.1002/bmb.21910.
Course-based undergraduate research experiences (CUREs) are important for providing undergraduates with authentic research experiences. At Xavier University of Louisiana, a Genetics Laboratory CURE course was developed and implemented. The goals of developing this Genetics CURE laboratory course were: (1) to provide a large number of students the opportunity to participate in a hypothesis-driven research project, (2) to determine the effect of different Msh6 missense variants on DNA mismatch repair (MMR), and (3) to provide opportunities to develop scientific communication skills. In the first 3 years of implementation, 595 students completed the course and participated in a project of evaluating DNA MMR utilizing the model organism, Saccharomyces cerevisiae. Students analyzed previously uncharacterized MSH6 alleles and summarized their findings by drafting a report in the style of a primary research article. Additionally, students communicated their findings in PowerPoint presentations, and some participated in poster presentations on campus. Examination of course evaluations indicated that students appreciated learning science theory and acquiring scientific skills in the context of a research project instead of as individual unconnected experiments.
基于课程的本科研究经历（CUREs）对于为本科生提供真实的研究经历非常重要。在路易斯安那州泽维尔大学，开发并实施了一门遗传学实验室CURE课程。开发这门遗传学CURE实验室课程的目标是：（1）为大量学生提供参与假设驱动研究项目的机会；（2）确定不同的Msh6错义变体对DNA错配修复（MMR）的影响；（3）提供培养科学交流技能的机会。在实施的前三年，595名学生完成了该课程，并参与了一个利用模式生物酿酒酵母评估DNA MMR的项目。学生们分析了以前未表征的MSH6等位基因，并通过撰写一篇初级研究文章风格的报告来总结他们的发现。此外，学生们在PowerPoint演示文稿中交流了他们的发现，一些学生还参加了校园海报展示。对课程评估的审查表明，学生们喜欢在研究项目的背景下学习科学理论并获得科学技能，而不是作为单独的、不相关的实验。
