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冷冻象鼻术与急性主动脉综合征患者的长期持续结果及最低再干预率

Sustained Long-Term Results with Minimal Reintervention Rates in Patients with Frozen Elephant Trunk and Acute Aortic Syndromes.

作者信息

Rorris Filippos-Paschalis, Pitros Christos F, Antonopoulos Constantine N, Papakonstantinou Konstantinos, Kokotsaki Lydia, Tsipas Pantelis, Gissis Ilias, Kokotsakis John

机构信息

Department of Thoracic and Cardiovascular Surgery, Evangelismos General Hospital, 10676 Athens, Greece.

1st Department of Vascular Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 75000 Athens, Greece.

出版信息

Med Sci (Basel). 2025 May 1;13(2):52. doi: 10.3390/medsci13020052.

DOI:10.3390/medsci13020052
PMID:40407547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12101257/
Abstract

The Frozen Elephant Trunk (FET) technique is indicated in acute aortic syndromes with arch involvement and malperfusion of tissues. We sought to report on long-term outcomes of FET in emergent cases of acute aortic syndromes. Twenty-three adult patients were referred to our department for surgical management of acute aortic syndromes and underwent aortic arch replacement using the FET technique between November 2010 and January 2022. The primary outcome was long-term survival. Secondary outcomes were the 30-day mortality rate and the incidence of neurologic complications, i.e., stroke and spinal cord ischemia. The mean patient age was 57.1 (±12.5) years, and the majority (20 patients, 87%) were male. The most common indication was Stanford type A acute aortic dissection (aTAAD) in 17 (74%) patients, followed by non-A non-B dissection in 2 (8.7%) patients, penetrating aortic ulcer (PAU) of the aortic arch in 2 (8.7%) patients, type A intramural hematoma (IMH) in 1 (4.3%) patient and blunt thoracic aortic injury of the aortic arch in 1 (4.3%) patient. Kaplan-Meier survival analysis revealed a 73% survival at 12 months, which persisted up to 11 years of follow-up. The FET technique provides a reliable solution for surgical management of patients with acute aortic syndromes. Excellent, sustained long-term results can be achieved.

摘要

“冰冻象鼻”(FET)技术适用于累及主动脉弓且存在组织灌注不良的急性主动脉综合征。我们试图报告FET技术在急性主动脉综合征急诊病例中的长期疗效。2010年11月至2022年1月期间,23例成年患者因急性主动脉综合征被转诊至我科接受手术治疗,并采用FET技术进行了主动脉弓置换。主要结局是长期生存。次要结局是30天死亡率和神经并发症的发生率,即中风和脊髓缺血。患者平均年龄为57.1(±12.5)岁,大多数(20例,87%)为男性。最常见的适应证是17例(74%)患者的斯坦福A型急性主动脉夹层(aTAAD),其次是2例(8.7%)患者的非A非B型夹层、2例(8.7%)患者的主动脉弓穿透性溃疡(PAU)、1例(4.3%)患者的A型壁内血肿(IMH)和1例(4.3%)患者的主动脉弓钝性胸主动脉损伤。Kaplan-Meier生存分析显示,12个月时生存率为73%,该生存率在长达11年的随访中持续存在。FET技术为急性主动脉综合征患者的手术治疗提供了可靠的解决方案。可以取得优异、持续的长期效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d98/12101257/47861fb9f821/medsci-13-00052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d98/12101257/47861fb9f821/medsci-13-00052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d98/12101257/47861fb9f821/medsci-13-00052-g001.jpg

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本文引用的文献

1
E-Vita OPEN NEO Hybrid Stent Graft: A New Frontier for Total Arch Replacement.E-Vita OPEN NEO混合支架型人工血管:全主动脉弓置换的新前沿。
Ann Vasc Surg. 2022 Aug;84:211-217. doi: 10.1016/j.avsg.2022.01.034. Epub 2022 Mar 3.
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Results of frozen elephant trunk from the international E-vita Open registry.国际E-vita Open注册研究中冰冻象鼻术的结果。
Ann Cardiothorac Surg. 2020 May;9(3):178-188. doi: 10.21037/acs-2020-fet-25.
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Neurologic complications after the frozen elephant trunk procedure: A meta-analysis of more than 3000 patients.
冷冻象鼻手术后的神经系统并发症:超过 3000 例患者的荟萃分析。
J Thorac Cardiovasc Surg. 2020 Jul;160(1):20-33.e4. doi: 10.1016/j.jtcvs.2019.10.031. Epub 2019 Oct 17.
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Editor's Choice - Current Options and Recommendations for the Treatment of Thoracic Aortic Pathologies Involving the Aortic Arch: An Expert Consensus Document of the European Association for Cardio-Thoracic Surgery (EACTS) & the European Society for Vascular Surgery (ESVS).编辑推荐——累及主动脉弓的胸主动脉病变治疗的当前选择与建议:欧洲心胸外科学会(EACTS)和欧洲血管外科学会(ESVS)专家共识文件
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Cerebrospinal fluid drainage during thoracic aortic repair: safety and current management.胸主动脉修复术中的脑脊液引流:安全性与当前管理
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