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游走于阻塞性睡眠呼吸暂停与衰老之间的微妙界限。

Walking the fine line between OSA and aging.

作者信息

Antonaglia Caterina, Fabozzi Antonio, Steffanina Alessia, Ture Riccardo, Palange Paolo, Confalonieri Marco

机构信息

Pulmonology Unit, Department of Medical Surgical and Health Sciences, Hospital of Cattinara, University of Trieste, 34149, Trieste, Italy.

Pulmonology Unit, Department of Public Health and Infectious Diseases, Pulmonary Division, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy.

出版信息

Sleep Breath. 2025 May 23;29(3):195. doi: 10.1007/s11325-025-03343-x.

Abstract

Obstructive Sleep Apnea (OSA) is the most common sleep- related breathing disorder. In recent years, evidence have shown that patients with OSA may have this disorder for different reasons, with different symptoms and comorbidities. Therefore, treatment should be individualized [1]. This has led to a growing interest in the characterization of the disease into phenotypes. OSA in elderly patients is often a challenge for clinician in terms of diagnosis, as symptoms may be masked, but also for treatment in terms of efficacy and adherence. However, aging is a pathophysiological factor that predisposes to obstructive sleep apnea, and the two conditions share symptoms and comorbidities to such an extent that it becomes very difficult to establish a casual link between the two. We summarize the recent evidence in OSA elderly patients, particularly in terms of pathophysiology, symptoms and main comorbidities.

摘要

阻塞性睡眠呼吸暂停(OSA)是最常见的与睡眠相关的呼吸障碍。近年来,有证据表明,患有阻塞性睡眠呼吸暂停的患者可能因不同原因、不同症状和合并症而患有这种疾病。因此,治疗应个体化[1]。这导致人们对将该疾病分为不同表型的特征越来越感兴趣。老年患者的阻塞性睡眠呼吸暂停在诊断方面对临床医生来说往往是一项挑战,因为症状可能被掩盖,而且在疗效和依从性方面的治疗也是如此。然而,衰老作为一种病理生理因素,易导致阻塞性睡眠呼吸暂停,而且这两种情况在症状和合并症方面有很大程度的重叠,以至于很难在两者之间建立因果联系。我们总结了近期关于老年阻塞性睡眠呼吸暂停患者的证据,特别是在病理生理学、症状和主要合并症方面。

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