OBJECTIVES: To evaluate the cultural acceptability and feasibility of the self-directed "My Health Priorities" (MHP) web-based program in older Southern African Americans (AAs) with multiple chronic conditions (MCCs) and their family caregivers (FCGs). DESIGN: A multi-method formative evaluation study (NIH Stage 1a) to explore patients' and FCGs' experiences with the MHP web-based program, a component of the patient priorities care approach. Interviews were analyzed using the constant comparative method and thematic analysis. Participants rated usability via the system usability scale (SUS) (scores range from 0 to 100). Sample characteristics were analyzed using SAS and SPSS. SETTING: A primary care clinic in a southeastern U.S. academic medical center. PARTICIPANTS: Fifteen older AAs with MCCs (≥ 65 years old, diagnosed with ≥ 2 chronic conditions) and their adult AA FCGs (≥ 18 years old). RESULTS: Participants generally found the program acceptable but difficult to navigate on devices other than computers. Suggestions included redesigning the avatar for cultural relevance, optimizing functionality for mobile devices, and offering strategies to address challenging patient-clinician interactions. Patients rated usability at 75.31 ± 14.63 (good usability), while FCGs rated it at 30.13 ± 4.31 (indicating limited usability). Study measures required 30 min to complete, while the intervention took 60 min. Participants completed 81% of study measures. CONCLUSIONS: Established web-based programs may be acceptable to AA patients and their caregivers, but specific technical and content aspects may need to be revised to make the programs more suitable for AAs. Design refinements should account for the differing usability experiences reported by AA patients and their caregivers. TRIAL REGISTRATION: NCT05129709.