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从MRI数据中获取特定受试者脑部特定吸收率图谱的可行性研究。

Feasibility study of subject-specific, brain specific-absorption-rate maps retrieved from MRI data.

作者信息

Martinez Jessica A, Zanovello Umberto, Arduino Alessandro, Hu Houchun Harry, Moulin Kevin, Ogier Stephen E, Bottauscio Oriano, Zilberti Luca, Keenan Kathryn E

机构信息

Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, Colorado, USA.

Department of Physics, University of Colorado Boulder, Boulder, Colorado, USA.

出版信息

Magn Reson Med. 2025 Sep;94(3):1136-1151. doi: 10.1002/mrm.30547. Epub 2025 May 24.

Abstract

INTRODUCTION

Specific absorption rate (SAR) is crucial for monitoring radiofrequency power absorption during MRI. Although local SAR distribution is usually calculated through numerical simulations, they are impractical during exams, limiting real-time patient-specific SAR assessment. This study confirms the feasibility of deriving in vivo, subject-specific, image-based SAR and 10-g SAR maps directly from MRI data.

METHODS

Complex B maps were derived by combining a B product (XFL) magnitude sequence with balanced steady-state free precession phase. Anatomical information and tissue masking were obtained from a T magnetization-prepared rapid gradient echo sequence. Electrical conductivity maps were generated from balanced steady-state free precession phase. Whole-brain SAR maps were created from MRI data acquired at 3 T using a 32-channel head coil on 2 healthy volunteers. A correction factor was applied to account for underestimation due to reliance on measurable B data. Numerical simulations compared image-based SAR with simulation-based SAR distributions.

RESULTS

A multi-slice image-based brain SAR map was obtained in 12 min (9-min acquisition, 3-min SAR reconstruction). In vitro experiments validated B distribution and electrical conductivity values. Calculated electrical conductivities for in vitro and in vivo experiments were within reference ranges. Image-based SAR and 10-g SAR maps showed a distribution similar to simulation-based maps (r = 0.5) after correction.

CONCLUSIONS

This study shows the feasibility of inline, subject-specific SAR and 10-g SAR maps from standard brain clinical sequences. Image-based SAR maps can be a practical alternative during MRI exams when simulations are not feasible.

摘要

引言

比吸收率(SAR)对于监测磁共振成像(MRI)期间的射频功率吸收至关重要。尽管局部SAR分布通常通过数值模拟计算,但在检查过程中这些方法不实用,限制了针对患者个体的实时SAR评估。本研究证实了直接从MRI数据中得出体内、个体特异性、基于图像的SAR和10克SAR图的可行性。

方法

通过将B乘积(XFL)幅度序列与平衡稳态自由进动相位相结合来推导复B图。从T磁化准备快速梯度回波序列中获取解剖学信息和组织掩膜。从平衡稳态自由进动相位生成电导率图。使用32通道头部线圈在3T下对2名健康志愿者采集MRI数据,创建全脑SAR图。应用校正因子以校正由于依赖可测量的B数据而导致的低估。数值模拟将基于图像的SAR与基于模拟的SAR分布进行比较。

结果

在12分钟内(9分钟采集,3分钟SAR重建)获得了基于多切片图像的脑SAR图。体外实验验证了B分布和电导率值。体外和体内实验计算得到的电导率均在参考范围内。校正后,基于图像的SAR和10克SAR图显示出与基于模拟的图相似的分布(r = 0.5)。

结论

本研究表明从标准脑临床序列中得出在线、个体特异性SAR和10克SAR图的可行性。当模拟不可行时,基于图像的SAR图在MRI检查期间可以是一种实用的替代方法。

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