Ashindoitiang John A, Nwagbara Victor Ic, Magam Dino N, Nnalue Victor D, Asuquo Maurice E
Department of Surgery, University of Calabar/University of Calabar Teaching Hospital, Nigeria.
Department of Surgery, University of Calabar Teaching Hospital, Nigeria.
J Int Med Res. 2025 May;53(5):3000605251343290. doi: 10.1177/03000605251343290. Epub 2025 May 24.
The inheritance of the sickle gene (hemoglobin S) and another abnormal hemoglobin gene is described as sickle cell disease, and the homozygous form of the disease is hemoglobin SS. In sickle cell disease, abdominal pain is a common symptom attributed to circulatory stasis and vascular occlusion, along with chest and musculoskeletal pain for which nonsteroidal anti-inflammatory drugs are often prescribed. This report presents the case of a 21-year-old man with sequential gastric and ileal perforations related to nonsteroidal anti-inflammatory drug usage. Gastrointestinal perforation should be considered as a differential diagnosis in patients who present with abdominal pain accompanied with symptoms such as peritonitis, shock, or sepsis. Furthermore, perforation may be sequential with perforation of the stomach followed by that of the ileum. The use of nonsteroidal anti-inflammatory drugs in patients with sickle cell disease requires further revaluation.
镰状基因（血红蛋白S）与另一种异常血红蛋白基因的遗传被描述为镰状细胞病，该病的纯合形式是血红蛋白SS。在镰状细胞病中，腹痛是一种常见症状，归因于循环淤滞和血管闭塞，同时还有胸痛和肌肉骨骼疼痛，非甾体抗炎药常被用于治疗这些疼痛。本报告介绍了一名21岁男性因使用非甾体抗炎药而先后出现胃和回肠穿孔的病例。对于出现腹痛并伴有腹膜炎、休克或败血症等症状的患者，应将胃肠道穿孔视为鉴别诊断之一。此外，穿孔可能是相继发生的，先是胃穿孔，随后是回肠穿孔。镰状细胞病患者使用非甾体抗炎药需要进一步重新评估。
