Bice D E, Muggenburg B A
Am Rev Respir Dis. 1985 Sep;132(3):661-5. doi: 10.1164/arrd.1985.132.3.661.
The effects of age on the number of lymphoid cells producing specific IgM antibody (AFC) and the level of specific IgM, IgG, and IgA antibody after lung immunization were evaluated in groups of dogs 2 through 16 yr of age. A trend for lowered antibody responses in blood was observed with increasing age, and significantly lowered antibody responses were measured in lavage fluids from immunized lung lobes of older dogs. Statistical evaluations indicated that the lowered antibody responses in the lung were due in part to the reduced AFC and level of specific antibody in the blood. However, a less intense inflammatory response to antigen instilled into the lungs of older dogs also significantly contributed to the lowered antibody responses in their lungs. Additional studies are needed to determine if the loss of inflammation and antibody responses in the lungs of aged dogs increases their susceptibility to pulmonary infections.
对2至16岁犬组进行评估，以研究年龄对肺部免疫后产生特异性IgM抗体的淋巴细胞数量（AFC）以及特异性IgM、IgG和IgA抗体水平的影响。随着年龄增长，血液中抗体反应呈降低趋势，且在老年犬免疫肺叶的灌洗液中测得抗体反应显著降低。统计评估表明，肺部抗体反应降低部分归因于血液中AFC和特异性抗体水平的降低。然而，老年犬肺部对抗原注入的炎症反应较弱也显著导致了其肺部抗体反应降低。需要进一步研究以确定老年犬肺部炎症和抗体反应的丧失是否会增加其肺部感染的易感性。
