人类和兔肺泡巨噬细胞对金属的溶解作用。
Dissolution of metals by human and rabbit alveolar macrophages.
作者信息
Lundborg M, Eklund A, Lind B, Camner P
出版信息
Br J Ind Med. 1985 Sep;42(9):642-5. doi: 10.1136/oem.42.9.642.
Abstract
The ability of human and rabbit alveolar macrophages to dissolve 0.1-0.5 micron MnO2 particles in vitro was compared. The amount of Mn added and dissolved from the particles over periods of nought, one, and three days was determined by flame atomic absorption spectrophotometry. The amount dissolved by human and rabbit macrophages was similar; on average 43.1% and 43.9%, respectively, were dissolved within three days. But rabbit and human macrophages dissolved significantly more Mn than was dissolved in the respective culture medium without macrophages after one and three days. It is suggested that the dissolution of particles by alveolar macrophages should be one basic component in any model of alveolar clearance of inorganic particles.
摘要
比较了人和兔肺泡巨噬细胞在体外溶解0.1 - 0.5微米二氧化锰颗粒的能力。通过火焰原子吸收分光光度法测定在零天、一天和三天期间从颗粒中添加和溶解的锰量。人和兔巨噬细胞溶解的量相似；三天内平均分别有43.1%和43.9%被溶解。但在一天和三天后，兔和人巨噬细胞溶解的锰明显多于各自无巨噬细胞的培养基中溶解的锰。提示肺泡巨噬细胞对颗粒的溶解应是无机颗粒肺泡清除任何模型中的一个基本组成部分。
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