Sobańska Zuzanna, Roszak Joanna, Kowalczyk Kornelia, Stępnik Maciej
Department of Translational Research, Nofer Institute of Occupational Medicine, 8 St Teresy St., 91-348 Łódź, Poland.
QSAR Lab Ltd., Trzy Lipy 3 St., 80-172 Gdańsk, Poland.
Nanomaterials (Basel). 2021 Apr 22;11(5):1084. doi: 10.3390/nano11051084.
The expanding applications of nanotechnology seem to be a response to many technological, environmental, and medical challenges. The unique properties of nanoparticles allow for developing new technologies and therapies. Among many investigated compounds is manganese and its oxides, which in the form of nanoparticles, could be a promising alternative for gadolinium-based contrast agents used in diagnostic imaging. Manganese, which is essential for living organisms as an enzyme cofactor, under excessive exposure-for example, due to water contamination or as an occupational hazard for welders-can lead to neurological disorders, including manganism-a condition similar to Parkinson's disease. This review attempts to summarise the available literature data on the potential applications of manganese and manganese oxide nanoparticles and their biological activity. Some of the published studies, both in vitro and in vivo, show negative effects of exposure to manganese, mainly on the nervous system, whereas other data suggest that it is possible to develop functionalised nanoparticles with negligible toxicity and novel promising properties.
纳米技术应用的不断拓展似乎是对诸多技术、环境和医学挑战的一种回应。纳米颗粒的独特性质有助于开发新技术和新疗法。在众多被研究的化合物中，锰及其氧化物以纳米颗粒的形式，可能成为诊断成像中使用的钆基造影剂的一种有前景的替代品。锰作为一种酶辅因子，对生物体至关重要，但在过度暴露的情况下——例如，由于水污染或作为焊工的职业危害——可能导致神经紊乱，包括锰中毒——一种类似于帕金森病的病症。这篇综述试图总结关于锰和氧化锰纳米颗粒的潜在应用及其生物活性的现有文献数据。一些已发表的体外和体内研究表明，接触锰主要对神经系统有负面影响，而其他数据则表明，有可能开发出毒性可忽略不计且具有新的有前景特性的功能化纳米颗粒。
