Chapman M G, Dowsett M, Dewhurst C J, Jeffcoate S L
Br J Obstet Gynaecol. 1985 Sep;92(9):983-5. doi: 10.1111/j.1471-0528.1985.tb03081.x.
The clinical efficacy of a combination of spironolactone and an oral contraceptive pill (Conova 30) was assessed in 23 patients presenting with hirsutism of whom 20 completed 6 months of treatment. Of the 20 patients, 16 showed improvement on objective (Ferriman & Gallwey hair score) and subjective assessment. Serum levels of androgens (testosterone, androstenedione and 17-hydroxy progesterone) were suppressed and sex hormone binding globulins were elevated. Nausea was the only significant side effect.
对23名多毛症患者评估了螺内酯与口服避孕药（Conova 30）联合使用的临床疗效，其中20名患者完成了6个月的治疗。在这20名患者中，16名在客观（费里曼和高尔韦毛发评分）和主观评估中显示有改善。雄激素（睾酮、雄烯二酮和17-羟孕酮）的血清水平受到抑制，性激素结合球蛋白升高。恶心是唯一显著的副作用。
