Grafova V N, Danilova E I
Biull Eksp Biol Med. 1985 Sep;100(9):273-5.
Experiments on noninbred rats were made to study the influence of lithium hydroxybutyrate on two patterns of spinal cord pathology: the generalized myoclonus and painful syndrome of spinal origin. The syndromes were induced by generators of pathologically enhanced excitation in the ventral and dorsal horns of the spinal cord. The effects of lithium chloride and sodium hydroxybutyrate were examined to compare the influence of lithium (cation) and hydroxybutyrate (anion) components to elucidate the role of each of the components. Lithium hydroxybutyrate appeared more effective, since it inhibited the generator of pathologically enhanced excitation in the appropriate structures, provoking the anticonvulsant effect in myoclonus and suppressing the painful syndrome.
对非近交系大鼠进行实验，以研究羟基丁酸锂对脊髓病理的两种模式的影响：全身性肌阵挛和脊髓源性疼痛综合征。这些综合征由脊髓腹角和背角病理性增强兴奋的发生器诱发。研究了氯化锂和羟基丁酸钠的作用，以比较锂（阳离子）和羟基丁酸（阴离子）成分的影响，从而阐明每种成分的作用。羟基丁酸锂似乎更有效，因为它抑制了相应结构中病理性增强兴奋的发生器，在肌阵挛中产生抗惊厥作用并抑制疼痛综合征。
