作为脊柱融合手术细胞疗法和多功能生物支架的椎骨骨髓凝块：一项随机临床试验方案 - Suppr

The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.

作者信息

Sartori Maria, Tedesco Giuseppe, Spinnato Paolo, Mazzotti Antonio, Gasbarrini Alessandro, Faldini Cesare, Miceli Marco, Giavaresi Gianluca, Salamanna Francesca

机构信息

Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

出版信息

Front Med (Lausanne). 2025 May 9;12:1591041. doi: 10.3389/fmed.2025.1591041. eCollection 2025.

DOI:10.3389/fmed.2025.1591041

PMID:40417680

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098565/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/6b209923138e/fmed-12-1591041-g001.jpg

相似文献

The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.作为脊柱融合手术细胞疗法和多功能生物支架的椎骨骨髓凝块：一项随机临床试验方案

Front Med (Lausanne). 2025 May 9;12:1591041. doi: 10.3389/fmed.2025.1591041. eCollection 2025.

Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study.自体骨髓凝块作为多功能生物支架在后路腰椎融合术中的安全性和有效性：一项为期 1 年的随访初步研究。

Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.

Vertebral Bone Marrow Clot towards the Routine Clinical Scenario in Spine Surgeries: What about the Antimicrobial Properties?脊柱手术中常规临床情况下的椎体骨髓血栓：抗菌性能如何？

Int J Mol Sci. 2023 Jan 16;24(2):1744. doi: 10.3390/ijms24021744.

Gender-Specific Differences in Human Vertebral Bone Marrow Clot.人类椎体骨髓栓子的性别特异性差异。

Int J Mol Sci. 2023 Jul 24;24(14):11856. doi: 10.3390/ijms241411856.

Randomized clinical trial: expanded autologous bone marrow mesenchymal cells combined with allogeneic bone tissue, compared with autologous iliac crest graft in lumbar fusion surgery.随机临床试验：与自体髂嵴植骨相比，扩增自体骨髓间充质细胞联合同种异体骨组织在腰椎融合术中的应用。

Spine J. 2020 Dec;20(12):1899-1910. doi: 10.1016/j.spinee.2020.07.014. Epub 2020 Jul 28.

Transpedicular aspiration of osteoprogenitor cells from the vertebral body: progenitor cell concentrations affected by serial aspiration.经椎弓根椎体抽吸成骨祖细胞：祖细胞浓度受连续抽吸的影响。

Spine J. 2009 Dec;9(12):995-1002. doi: 10.1016/j.spinee.2009.08.455.

Spine fusion using cell matrix composites enriched in bone marrow-derived cells.使用富含骨髓来源细胞的细胞基质复合材料进行脊柱融合术。

Clin Orthop Relat Res. 2003 Feb(407):102-18. doi: 10.1097/00003086-200302000-00018.

Only prolonged time from abstraction found to affect viable nucleated cell concentrations in vertebral body bone marrow aspirate.仅发现从采集到处理的时间延长会影响椎体骨髓抽吸物中有活力的有核细胞浓度。

Spine J. 2014 Jun 1;14(6):990-5. doi: 10.1016/j.spinee.2013.10.021. Epub 2013 Nov 1.

Optimal aspiration volume of vertebral bone marrow for use in spinal fusion.用于脊柱融合的最佳椎骨骨髓抽吸量。

Spine J. 2013 Oct;13(10):1217-22. doi: 10.1016/j.spinee.2013.07.435. Epub 2013 Sep 25.

Short-segment spinal fusion for chronic low back pain with bone marrow edema adjacent to the vertebral endplate in adult spinal deformity.成人退变性脊柱畸形中临近椎体终板骨髓水肿的慢性下腰痛行短节段脊柱融合术。

Eur Spine J. 2024 Mar;33(3):1061-1068. doi: 10.1007/s00586-023-08028-1. Epub 2023 Dec 11.

本文引用的文献

Risk factors affecting spinal fusion: A meta-analysis of 39 cohort studies.影响脊柱融合的风险因素：39 项队列研究的荟萃分析。

PLoS One. 2024 Jun 7;19(6):e0304473. doi: 10.1371/journal.pone.0304473. eCollection 2024.

Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.

Two Hits for Bone Regeneration in Aged Patients: Vertebral Bone Marrow Clot as a Biological Scaffold and Powerful Source of Mesenchymal Stem Cells.老年患者骨再生的双重作用：椎体骨髓凝块作为生物支架和间充质干细胞的强大来源。

Front Bioeng Biotechnol. 2022 Jan 18;9:807679. doi: 10.3389/fbioe.2021.807679. eCollection 2021.

New Strategies in Enhancing Spinal Fusion.增强脊柱融合的新策略

HSS J. 2020 Jul;16(2):177-182. doi: 10.1007/s11420-020-09749-5. Epub 2020 Feb 2.

A Rationale for the Use of Clotted Vertebral Bone Marrow to Aid Tissue Regeneration Following Spinal Surgery.使用结扎的椎骨骨髓促进脊柱手术后组织再生的基本原理。

Sci Rep. 2020 Mar 5;10(1):4115. doi: 10.1038/s41598-020-60934-2.

Orthobiologics in minimally invasive lumbar fusion.微创腰椎融合术中的骨科生物制剂

J Spine Surg. 2019 Jun;5(Suppl 1):S11-S18. doi: 10.21037/jss.2019.04.15.

Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix.腰椎融合术的临床与CT分析：β-磷酸三钙与脱矿骨基质的比较

J Am Acad Orthop Surg Glob Res Rev. 2018 Sep 12;2(9):e024. doi: 10.5435/JAAOSGlobal-D-18-00024. eCollection 2018 Sep.

Biological Rationale for the Use of Vertebral Whole Bone Marrow in Spinal Surgery.用于脊柱手术的脊柱全骨骨髓的生物学基础。

Spine (Phila Pa 1976). 2018 Oct 15;43(20):1401-1410. doi: 10.1097/BRS.0000000000002626.

Osteoporosis and the Management of Spinal Degenerative Disease (I).骨质疏松症与脊柱退行性疾病的管理（一）

Arch Bone Jt Surg. 2017 Sep;5(5):272-282.

Combination of bone marrow mesenchymal stem cells sheet and platelet rich plasma for posterolateral lumbar fusion.骨髓间充质干细胞片与富血小板血浆联合用于腰椎后外侧融合术

Oncotarget. 2017 Jul 31;8(37):62298-62311. doi: 10.18632/oncotarget.19749. eCollection 2017 Sep 22.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.

作者信息

机构信息

出版信息

相似文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

本文引用的文献