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The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.

作者信息

Sartori Maria, Tedesco Giuseppe, Spinnato Paolo, Mazzotti Antonio, Gasbarrini Alessandro, Faldini Cesare, Miceli Marco, Giavaresi Gianluca, Salamanna Francesca

机构信息

Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

出版信息

Front Med (Lausanne). 2025 May 9;12:1591041. doi: 10.3389/fmed.2025.1591041. eCollection 2025.

DOI:10.3389/fmed.2025.1591041
PMID:40417680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098565/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/3507a0091e5a/fmed-12-1591041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/6b209923138e/fmed-12-1591041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/3507a0091e5a/fmed-12-1591041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/6b209923138e/fmed-12-1591041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/12098565/3507a0091e5a/fmed-12-1591041-g002.jpg

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The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.作为脊柱融合手术细胞疗法和多功能生物支架的椎骨骨髓凝块：一项随机临床试验方案
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2
Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study.自体骨髓凝块作为多功能生物支架在后路腰椎融合术中的安全性和有效性：一项为期 1 年的随访初步研究。
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本文引用的文献

1
Risk factors affecting spinal fusion: A meta-analysis of 39 cohort studies.影响脊柱融合的风险因素：39 项队列研究的荟萃分析。
PLoS One. 2024 Jun 7;19(6):e0304473. doi: 10.1371/journal.pone.0304473. eCollection 2024.
2
Safety and efficacy of autologous bone marrow clot as a multifunctional bioscaffold for instrumental posterior lumbar fusion: a 1-year follow-up pilot study.自体骨髓凝块作为多功能生物支架在后路腰椎融合术中的安全性和有效性：一项为期 1 年的随访初步研究。
Front Endocrinol (Lausanne). 2024 Jan 8;14:1245344. doi: 10.3389/fendo.2023.1245344. eCollection 2023.
3
Two Hits for Bone Regeneration in Aged Patients: Vertebral Bone Marrow Clot as a Biological Scaffold and Powerful Source of Mesenchymal Stem Cells.
老年患者骨再生的双重作用：椎体骨髓凝块作为生物支架和间充质干细胞的强大来源。
Front Bioeng Biotechnol. 2022 Jan 18;9:807679. doi: 10.3389/fbioe.2021.807679. eCollection 2021.
4
New Strategies in Enhancing Spinal Fusion.增强脊柱融合的新策略
HSS J. 2020 Jul;16(2):177-182. doi: 10.1007/s11420-020-09749-5. Epub 2020 Feb 2.
5
A Rationale for the Use of Clotted Vertebral Bone Marrow to Aid Tissue Regeneration Following Spinal Surgery.使用结扎的椎骨骨髓促进脊柱手术后组织再生的基本原理。
Sci Rep. 2020 Mar 5;10(1):4115. doi: 10.1038/s41598-020-60934-2.
6
Orthobiologics in minimally invasive lumbar fusion.微创腰椎融合术中的骨科生物制剂
J Spine Surg. 2019 Jun;5(Suppl 1):S11-S18. doi: 10.21037/jss.2019.04.15.
7
Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix.腰椎融合术的临床与CT分析：β-磷酸三钙与脱矿骨基质的比较
J Am Acad Orthop Surg Glob Res Rev. 2018 Sep 12;2(9):e024. doi: 10.5435/JAAOSGlobal-D-18-00024. eCollection 2018 Sep.
8
Biological Rationale for the Use of Vertebral Whole Bone Marrow in Spinal Surgery.用于脊柱手术的脊柱全骨骨髓的生物学基础。
Spine (Phila Pa 1976). 2018 Oct 15;43(20):1401-1410. doi: 10.1097/BRS.0000000000002626.
9
Osteoporosis and the Management of Spinal Degenerative Disease (I).骨质疏松症与脊柱退行性疾病的管理（一）
Arch Bone Jt Surg. 2017 Sep;5(5):272-282.
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Combination of bone marrow mesenchymal stem cells sheet and platelet rich plasma for posterolateral lumbar fusion.骨髓间充质干细胞片与富血小板血浆联合用于腰椎后外侧融合术
Oncotarget. 2017 Jul 31;8(37):62298-62311. doi: 10.18632/oncotarget.19749. eCollection 2017 Sep 22.