Zhu Jiaxue, Yang Ling, Yang Qing, Huang Yin, Li Yuhang, He Yueqing, Yang Xuxu, Yang Zhiyan, Jiao Yonghong, Wei Wenbin, Chen Yihao, Feng Xue
Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing, 100084, China.
AML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China.
Adv Healthc Mater. 2025 Jul;14(18):e2402148. doi: 10.1002/adhm.202402148. Epub 2025 May 26.
Severe corneal dysfunctions caused by corneal hypoxia and microenvironmental imbalance threaten hundreds of millions of people's eye health, leading to neovascularization, keratitis, and even vision loss, particularly among contact lens wearers. However, there are no accessible digital tools for wearable and continuous monitoring of corneal oxygen and microenvironment status. Here, a kirigami-inspired breathable smart contact lens for wireless monitoring of corneal hypoxia and microenvironment is presented. The ultrathin (55 µm) and flexible sensing device enables digitalized, in situ and precise monitoring of key eye health indicators: dissolved oxygen, humidity, and temperature (R > 0.98). The flexible circuit, designed and processed using evolutionary kirigami structures and thermoforming, efficiently conforms to the soft curved surfaces with minimized contour dimensions and residual stress. Silicone/hydrogel hybrid layers encapsulate the electronics, achieving high oxygen permeability (380.26 Barrers), sufficient water content (>80%), and excellent biocompatibility/heat safety. In vivo animal experiments in beagle eyes demonstrate the lens's capability for accurate, wireless corneal monitoring under controlled conditions.
由角膜缺氧和微环境失衡引起的严重角膜功能障碍威胁着数亿人的眼部健康，导致新生血管形成、角膜炎，甚至视力丧失，在隐形眼镜佩戴者中尤为常见。然而，目前尚无用于可穿戴和连续监测角膜氧气及微环境状态的便捷数字工具。在此，我们展示了一种受折纸启发的透气智能隐形眼镜，用于无线监测角膜缺氧和微环境。这种超薄（55微米）且灵活的传感装置能够对关键眼部健康指标进行数字化、原位和精确监测：溶解氧、湿度和温度（R>0.98）。采用进化折纸结构和热成型设计与加工的柔性电路，能以最小化的轮廓尺寸和残余应力高效贴合柔软的曲面。硅酮/水凝胶混合层包裹电子元件，实现了高透氧性（380.26巴雷尔）、充足的含水量（>80%）以及出色的生物相容性/热安全性。在比格犬眼部进行的体内动物实验证明了该隐形眼镜在可控条件下进行准确无线角膜监测的能力。
