School of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Nat Commun. 2024 Feb 26;15(1):1766. doi: 10.1038/s41467-024-46049-6.
The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs' blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye's axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.
眼球的适当轴向长度对于实现正视至关重要。在这项研究中，我们提出了一种无线无电池的眼部调制贴，旨在矫正高度近视并防止复发。该贴片由压电换能器、电化学微执行器、药物微针阵列、μ-LED、柔性电路和生物相容性封装组成。该系统可以使用外部超声进行无线供电和控制。电化学微执行器通过向内驱动后巩膜在精确缩短轴向长度方面发挥关键作用。这确保了近视眼中视网膜上的精确场景成像。药物微针阵列将核黄素递送至后巩膜，μ-LED 的蓝光诱导胶原交联，增强巩膜强度。体内实验表明，该贴片成功地将兔眼的轴向长度减少了约 1217μm，并将巩膜强度提高了 387%。该系统在体内有效运行，无需电池。在这里，我们表明该贴片为临床治疗高度近视提供了有前途的途径。
