Department of Materials Science and Engineering, Center for Nanomedicine Institute for Basic Science (IBS), Yonsei University, Seoul, 03722, Republic of Korea.
Department of Biomedical Science, The Graduate School, Kyungpook National University, 680 Gukchebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.
Adv Sci (Weinh). 2022 Oct;9(28):e2203597. doi: 10.1002/advs.202203597. Epub 2022 Aug 17.
Herein, a wireless and soft smart contact lens that enables real-time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol-related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.
本文报道了一种无线、柔软的智能隐形眼镜，它可以实时定量记录泪液中的胆固醇，通过智能手机监测高血脂患者。该隐形眼镜结合了电化学生物传感器来持续检测胆固醇浓度、可拉伸天线和集成电路用于无线通信，这使得智能手机成为远程操作该隐形眼镜的唯一设备，而不会妨碍佩戴者的视力。利用高血脂兔模型证实了泪液和血液中的胆固醇水平之间的相关性，并证实了这种智能隐形眼镜在胆固醇相关疾病诊断应用中的可行性。进一步的人体试验证明了其作为一种非侵入性医疗保健设备的良好生物相容性、佩戴舒适性和可靠性。
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