Hu Yuqing, Xu Wenxia, Chen Lin
Central Laboratory and Precision Medicine Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Jinhua Key Laboratory of Cancer Nutrition and Metabolism Research, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Discov Oncol. 2025 May 26;16(1):929. doi: 10.1007/s12672-025-02674-1.
Metabolic reprogramming occurs alongside tumor development. As cancers advance from precancerous lesions to locally invasive tumors and then to metastatic tumors, metabolic patterns exhibit distinct changes, including mutations in metabolic enzymes and modifications in the activity of metabolic regulatory proteins. Alterations in metabolic patterns can influence tumor evolution, either establishing or alleviating metabolic burdens and facilitating cancer growth. To fully understand how metabolic reprogramming helps tumors grow and find the metabolic activities that are most useful for treating tumors, we need to have a deeper understanding of how metabolic patterns are controlled as tumors grow. Post-translational modifications (PTMs), a critical mechanism in the regulation of protein function, can influence protein activity, stability, and interactions in several ways. In tumor cells, PTMs-mediated metabolic reprogramming is a crucial mechanism for adapting to the challenging microenvironment and sustaining fast growth. This article will deeply explore the intricate regulatory mechanism of PTMs on metabolic reprogramming and its role in tumor progression, with the expectation of providing new theoretical basis and potential targets for tumor treatment.
代谢重编程与肿瘤发展同步发生。随着癌症从前体病变发展为局部浸润性肿瘤，进而发展为转移性肿瘤，代谢模式呈现出明显变化，包括代谢酶的突变以及代谢调节蛋白活性的改变。代谢模式的改变可影响肿瘤进展，既可能加重也可能减轻代谢负担并促进癌症生长。为了全面了解代谢重编程如何助力肿瘤生长并找出对治疗肿瘤最有用的代谢活动，我们需要更深入地了解随着肿瘤生长代谢模式是如何被调控的。翻译后修饰（PTMs）作为调节蛋白质功能的关键机制，可通过多种方式影响蛋白质活性、稳定性及相互作用。在肿瘤细胞中，PTMs介导的代谢重编程是适应具有挑战性的微环境并维持快速生长的关键机制。本文将深入探讨PTMs对代谢重编程的复杂调控机制及其在肿瘤进展中的作用，以期为肿瘤治疗提供新的理论依据和潜在靶点。
