Wu Xiaoke, Shi Mengmeng, Zhang Haifeng, Fang Shaokuan
Department of Neurology, Neuroscience Centre, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.
Sci Rep. 2025 May 26;15(1):18301. doi: 10.1038/s41598-025-03122-4.
Evidence on the relationship between dietary zinc intake and stroke in American populations is limited. This study aimed to investigate the association between dietary zinc consumption and stroke prevalence among US adults. This cross-sectional study analyzed data from adults (≥ 18 years) who participated in the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2020. Dietary zinc intake, stroke history, and other relevant factors were examined. Logistic regression models were used to assess the association between dietary zinc consumption and stroke risk, while restricted cubic splines (RCS) were applied to explore potential non-linear relationships. A total of 2642 adults from four NHANES cycles (2013-2020) were included in the analysis. In multivariate logistic regression, individuals in the second quartile of dietary zinc intake (Q2: 6.09-8.83 mg/day) had a significantly lower odds ratio (OR) for stroke (OR = 0.64, 95% confidence interval (CI) 0.41-0.99, p = 0.044) compared with those in the lowest quartile (Q1: ≤6.08 mg/day). RCS analysis indicated an L-shaped relationship between dietary zinc intake and stroke odds (p = 0.041). Threshold analysis revealed that for individuals consuming less than 8.82 mg of zinc daily, the OR for stroke was 0.858 (95% CI 0.74-0.99, p = 0.037). Our findings suggest an L-shaped association between dietary zinc intake and stroke prevalence in American adults, with higher zinc intake associated with lower odds of stroke within a specific intake range.
关于美国人群饮食锌摄入量与中风之间关系的证据有限。本研究旨在调查美国成年人饮食锌摄入量与中风患病率之间的关联。这项横断面研究分析了2013年至2020年期间参与美国国家健康与营养检查调查（NHANES）的成年人（≥18岁）的数据。研究了饮食锌摄入量、中风病史及其他相关因素。采用逻辑回归模型评估饮食锌摄入量与中风风险之间的关联，同时应用限制性立方样条（RCS）来探索潜在的非线性关系。分析纳入了来自四个NHANES周期（2013 - 2020年）的2642名成年人。在多变量逻辑回归中，饮食锌摄入量处于第二四分位数（Q2：6.09 - 8.83毫克/天）的个体，与处于最低四分位数（Q1：≤6.08毫克/天）的个体相比，中风的优势比（OR）显著更低（OR = 0.64，95%置信区间（CI）0.41 - 0.99，p = 0.044）。RCS分析表明饮食锌摄入量与中风优势之间呈L形关系（p = 0.041）。阈值分析显示，对于每日锌摄入量低于8.82毫克的个体，中风的OR为0.858（95% CI 0.74 - 0.99，p = 0.037）。我们的研究结果表明，美国成年人饮食锌摄入量与中风患病率之间呈L形关联，在特定摄入范围内，锌摄入量越高，中风几率越低。
