Lee Yu-Po, Chan Hui-Ting, Li Tzu-Hsuan, Chu Lichieh Julie, Lee Sheau-Long, Chang Yu-Quan, Wang Robert Yl
Biotechnology Industry Master and Ph.D. Program, Chang Gung University, Taoyuan 333323, Taiwan.
Wellhead Biological Technology Corp., Taoyuan 325019, Taiwan.
Diseases. 2025 May 5;13(5):143. doi: 10.3390/diseases13050143.
Cancer, also known as malignant tumors, is formed due to abnormal mutations and the proliferation of human cells. Cancer cells not only demonstrate accelerated proliferation but also show robust invasive and metastatic potential, disseminating from a primary affected region of the body to multiple areas and potentially culminating in organ dysfunction or failure, thereby jeopardizing the individual's life. The rapid growth of the biopharmaceutical market has given rise to numerous novel medicines, thereby precipitating a paradigm shift in contemporary drug development methodologies. This modification is focused on identifying methodologies that can effectively target cancerous cells while minimizing damage to normal cells. There is an increasing societal movement that supports the utilization of natural ingredients derived from plants. In recent years, traditional herbal medicine has experienced a surge in popularity within the global cancer market. In comparison with the use of more toxic chemotherapy methods, there has been an increasing focus on advanced therapies that exhibit reduced side effects. Ginsenoside compound K (CK) is derived from the natural components in ginseng through biotransformation. The utilization of CK in cancer research is a practice engaged in by numerous scientists. The underlying rationale is that CK exhibits a multitude of effects within the realm of cancer research, including but not limited to the mitigation of inflammation, the suppression of cancerous cell proliferation, and the safeguarding of cardiovascular, hepatic, and renal functions. This review methodically identifies and organizes CK-related journals according to the following key points of cancer treatment: the effects on cancer cells themselves, angiogenesis inhibition, modulation of immune response to identify cancer cells, and inflammation regulation. The intricate interplay between ginsenoside CK and cells is elucidated through a graphical representation. The present review focuses on the results of CK in in vitro tests. It is our hope that the present article will aid future studies on the results of CK in vivo tests, clarify the correlation between cellular mechanisms in vivo and in vitro tests, and assist in the development of drugs.
癌症，也被称为恶性肿瘤，是由于人体细胞的异常突变和增殖而形成的。癌细胞不仅表现出加速增殖，还具有强大的侵袭和转移潜力，从身体的原发性受累区域扩散到多个部位，并可能最终导致器官功能障碍或衰竭，从而危及个体生命。生物制药市场的快速增长催生了众多新型药物，从而引发了当代药物开发方法的范式转变。这种转变侧重于寻找能够有效靶向癌细胞同时将对正常细胞的损害降至最低的方法。社会上越来越多的人支持使用植物来源的天然成分。近年来，传统草药在全球癌症市场中越来越受欢迎。与使用毒性更大的化疗方法相比，人们越来越关注副作用较小的先进疗法。人参皂苷Compound K（CK）是通过生物转化从人参中的天然成分衍生而来的。众多科学家都在癌症研究中使用CK。其基本原理是CK在癌症研究领域表现出多种作用，包括但不限于减轻炎症、抑制癌细胞增殖以及保护心血管、肝脏和肾脏功能。本综述根据癌症治疗的以下关键点系统地识别和整理与CK相关的期刊：对癌细胞本身的影响、抑制血管生成、调节对癌细胞的免疫反应以及炎症调节。通过图形表示阐明了人参皂苷CK与细胞之间的复杂相互作用。本综述重点关注CK在体外试验中的结果。我们希望本文将有助于未来关于CK体内试验结果的研究，阐明体内和体外试验中细胞机制之间的相关性，并协助药物开发。
