甲磺酸甲酯与乙酸甲基偶氮甲醇在大鼠小肠和肝脏中的同步致癌作用。
Syncarcinogenic effects of methyl methanesulfonate with methylazoxymethanol acetate in rat small intestine and liver.
作者信息
Mori H, Kuniyasu T, Sugie S, Shima H, Takahashi M
出版信息
Carcinogenesis. 1985 Oct;6(10):1529-31. doi: 10.1093/carcin/6.10.1529.
PMID:4042281
Abstract
The carcinogenic potency of methyl methanesulfonate (MMS) and its combination effect with methylazoxymethanol (MAM) acetate were evaluated in rats. MMS was suggested to be weakly carcinogenic for the small intestine. Syncarcinogenic effects of MMS and MAM acetate which could be due to summation of their genotoxic influences were obtained in the small intestine and liver.
摘要
在大鼠中评估了甲磺酸甲酯（MMS）的致癌潜力及其与乙酸甲基偶氮甲醇（MAM）的联合效应。MMS被认为对小肠有弱致癌性。在小肠和肝脏中发现了MMS和乙酸MAM的协同致癌作用，这可能是由于它们的遗传毒性影响的总和。
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