Inhibitory effect of chlorogenic acid on methylazoxymethanol acetate-induced carcinogenesis in large intestine and liver of hamsters.

The effect of dietary chlorogenic acid on methylazoxymethanol (MAM) acetate-induced carcinogenesis was examined in Syrian golden hamsters. The combined incidence of total large intestinal tumors from male and female hamsters, and the combined incidence of large intestinal adenocarcinomas or the incidence of the carcinomas of male or female animals of the group given a single intravenous injection of MAM acetate (20 mg/kg body wt) and then fed the diet containing 0.025% chlorogenic acid for 24 weeks were significantly lower than those of hamsters given MAM acetate alone. The numbers of hyperplastic liver cell foci in male and female hamsters given MAM acetate and chlorogenic acid were also significantly smaller than those of hamsters given MAM acetate alone. These results indicate an inhibitory effect of chlorogenic acid on MAM acetate-induced carcinogenesis in hamsters.