具有长表面等离子体共振峰波长的金纳米笼作为用于1060nm光学相干断层扫描成像的造影剂

Gold Nanocages with a Long Surface Plasmon Resonance Peak Wavelength as Contrast Agents for Optical Coherence Tomography Imaging at 1060 nm.

作者信息

Chen Yongping, Xi Jiefeng, Le Vinh Nguyen Du, Ramella-Roman Jessica, Li Xingde

机构信息

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.

Noble Life Sciences, Sykesville, MD 21784, USA.

出版信息

Nanomaterials (Basel). 2025 May 18;15(10):755. doi: 10.3390/nano15100755.

DOI:10.3390/nano15100755

PMID:40423145

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12113713/

Abstract

There is growing interest in optical coherence tomography (OCT) imaging at a wavelength of 1060 nm. However, potential contrast agents for OCT imaging at this specific wavelength has not been thoroughly investigated. In this study, we present the synthesis and optical characterization of gold nanocages with a small edge length (~65 nm) and a surface plasmon resonance peak around 1060 nm. These nanocages represent a class of potential contrast agents for OCT at 1060 nm. OCT imaging experiments were conducted on phantoms and in vivo mouse tissues using a 1060 nm swept-source OCT system, demonstrating significant enhancement in imaging contrast due to the presence of the gold nanocages.

摘要

目前，人们对波长为1060 nm的光学相干断层扫描（OCT）成像的兴趣与日俱增。然而，针对该特定波长的OCT成像的潜在造影剂尚未得到充分研究。在本研究中，我们展示了边长较小（约65 nm）且表面等离子体共振峰在1060 nm左右的金纳米笼的合成及光学特性。这些纳米笼代表了一类用于1060 nm OCT成像的潜在造影剂。使用1060 nm扫频源OCT系统对模型和小鼠活体组织进行了OCT成像实验，结果表明由于金纳米笼的存在，成像对比度有显著增强。