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非洲基因组监测的理由。

The Case for Genomic Surveillance in Africa.

作者信息

Ochola Rachel

机构信息

School of Health, Department of Biomedical Sciences, Technical University of Kenya, Nairobi P.O. Box 52428-00200, Kenya.

出版信息

Trop Med Infect Dis. 2025 May 8;10(5):129. doi: 10.3390/tropicalmed10050129.

DOI:10.3390/tropicalmed10050129
PMID:40423359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12115357/
Abstract

Sub-Saharan Africa has made remarkable strides in genomic surveillance, with more than 50% of countries now equipped with an in-country sequencing capacity and 98% actively contributing data to public genomic repositories. Catalyzed by the momentum of the COVID-19 pandemic, these advancements have extended far beyond SARS-CoV-2 to address a broader spectrum of public health threats, including antimicrobial resistance (AMR) and other emerging infectious diseases. This review explores these transformative achievements, identifies remaining gaps, and outlines strategic priorities for embedding genomics into the continent's health systems. With a focus on sustainability, equity, and cross-sector collaboration, it positions Africa as a driver of global innovation in pathogen surveillance, uniquely leveraging its genetic and epidemiological diversity.

摘要

撒哈拉以南非洲在基因组监测方面取得了显著进展,目前超过50%的国家具备国内测序能力,98%的国家积极向公共基因组数据库贡献数据。在新冠疫情的推动下,这些进展已远远超出了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的范畴,以应对更广泛的公共卫生威胁,包括抗菌药物耐药性(AMR)和其他新发传染病。本综述探讨了这些变革性成就,找出了尚存的差距,并概述了将基因组学融入非洲大陆卫生系统的战略重点。它以可持续性、公平性和跨部门合作为重点,将非洲定位为全球病原体监测创新的推动者,独特地利用其遗传和流行病学多样性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7994/12115357/d0f637346884/tropicalmed-10-00129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7994/12115357/d0f637346884/tropicalmed-10-00129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7994/12115357/d0f637346884/tropicalmed-10-00129-g001.jpg

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本文引用的文献

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Increasing the genomic workforce through research capacity building: Designing evaluation plans for maximum impact.通过研究能力建设增加基因组学领域的专业人员数量:设计具有最大影响力的评估计划。
Am J Hum Genet. 2025 May 1;112(5):967-974. doi: 10.1016/j.ajhg.2025.03.002. Epub 2025 Apr 2.
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Cross-border data sharing for research in Africa: an analysis of the data protection and research ethics requirements in 12 jurisdictions.非洲研究中的跨境数据共享:对12个司法管辖区数据保护和研究伦理要求的分析
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The rise of pathogen genomics in Africa.
非洲病原体基因组学的兴起。
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Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024.2024 年,刚果民主共和国南基伍省卡米图加正在发生的猴痘疫情与新型 I 分支的一个新亚谱系猴痘病毒有关。
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Current Uses and Future Perspectives of Genomic Technologies in Clinical Microbiology.基因组技术在临床微生物学中的当前应用及未来展望
Antibiotics (Basel). 2023 Oct 30;12(11):1580. doi: 10.3390/antibiotics12111580.
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EMBL's European Bioinformatics Institute (EMBL-EBI) in 2022.2022 年,欧洲分子生物学实验室的欧洲生物信息学研究所(EMBL-EBI)。
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