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研究 SARS-CoV-2 基因组数据的生成,以评估基因组学在流行病学监测和公共卫生决策中的引入。

Study of the SARS-CoV-2 genomic data generation to evaluate the introduction of genomics in epidemiological surveillance and public health decision making.

机构信息

Département des Sciences de la Vie et de la Terre, Faculté des Sciences et Techniques, Université de Kara, Kara, Togo.

Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China.

出版信息

Pan Afr Med J. 2022 Jan 20;41:55. doi: 10.11604/pamj.2022.41.55.32344. eCollection 2022.

DOI:10.11604/pamj.2022.41.55.32344
PMID:35317482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8917452/
Abstract

INTRODUCTION

the limited number of equipped laboratories and the lack of expertise left Africa lagging behind in terms of contribution in genomic data generation. The COVID-19 pandemic has drawn the attention of all public health stakeholders so that it can be used as a marker of the efforts that public health systems can produced. The main purpose of the present analytical study was to evaluate the contribution of the African continent in the genomic surveillance of SARS-CoV-2.

METHODS

data from the two most popular genomic databases on SARS-CoV-2 (GISAID EpiCov and NCBI Virus) were extracted and analyzed. Comparisons were made using the sequencing ratio which represents the number of genomic sequence published over one thousands confirmed cases.

RESULTS

considering continental blocks, the Africa occupied the fourth place after Oceania, Europe and North America based on sequencing ratios. However, when the considered comparison parameter is the number of sequences, the African continent was the fifth contributor after Europe, North America, Asia and South America.

CONCLUSION

the study showed that African countries have effectively integrated the genomic data generation in the public health response strategies but the effective use of these data for a perfect surveillance is not clearly established. There is a need for capacity building in genomic data analyses for a better response to public health threats in Africa.

摘要

引言

由于配备的实验室数量有限且缺乏专业知识,非洲在基因组数据生成方面的贡献相对较少。新冠疫情引起了所有公共卫生利益攸关方的关注,可以将其作为公共卫生系统能够产生的努力的标志。本分析研究的主要目的是评估非洲大陆在 SARS-CoV-2 基因组监测方面的贡献。

方法

从两个最受欢迎的 SARS-CoV-2 基因组数据库(GISAID EpiCov 和 NCBI Virus)中提取和分析数据。使用测序比率进行比较,测序比率表示已发布的基因组序列数量与已确认病例数的比值。

结果

就大陆板块而言,非洲在测序比率方面仅次于大洋洲、欧洲和北美洲,位居第四。然而,当考虑到序列数量这一比较参数时,非洲大陆是继欧洲、北美洲、亚洲和南美洲之后的第五大贡献者。

结论

该研究表明,非洲国家已有效地将基因组数据生成纳入公共卫生应对策略中,但这些数据的有效利用以实现完善的监测尚未得到明确确立。需要在基因组数据分析方面进行能力建设,以更好地应对非洲的公共卫生威胁。