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Delayed removal of renal-bound antigen in decomplemented rabbits with acute serum sickness.补体缺乏的急性血清病兔体内肾结合抗原的延迟清除
Clin Exp Immunol. 1978 May;32(2):199-206.
2
Complement fixation in acute serum sickness: assembly of glomerular-bound C3-convertase.急性血清病中的补体固定：肾小球结合的C3转化酶的组装。
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[Complement-mediated solubilization of immune complexes in immune complex nephritis].[补体介导的免疫复合物性肾炎中免疫复合物的溶解作用]
Nihon Jinzo Gakkai Shi. 1989 Aug;31(8):807-13.
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Endogenous immune complex nephropathy associated with malignancy I. Studies on the nature and immunopathogenic significance of glomerular bound antigen and antibody, isolation and characterization of tumor specific antigen and antibody and circulating immune complexes.与恶性肿瘤相关的内源性免疫复合物肾病I. 肾小球结合抗原和抗体的性质及免疫致病意义、肿瘤特异性抗原和抗体的分离与鉴定以及循环免疫复合物的研究
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Induction of extraglomerular renal damage in experimental chronic serum sickness. I. Histologic and immunofluorescence findings.实验性慢性血清病中肾小球外肾损伤的诱导。I. 组织学和免疫荧光检查结果。
Lab Invest. 1979 May;40(5):603-14.
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Platelet involvement in the nephritis of acute serum sickness in rabbits: protection by dipyridamole and FUT-175.血小板在兔急性血清病肾炎中的作用：双嘧达莫和FUT-175的保护作用
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Chronic serum sickness glomerulonephritis: removal of glomerular antigen and electron-dense deposits is largely dependent on plasma complement.慢性血清病性肾小球肾炎：肾小球抗原和电子致密沉积物的清除很大程度上依赖于血浆补体。
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8
Localization of cationic proteins derived from platelets and polymorphonuclear neutrophils and local loss of anionic sites in glomeruli of rabbits with experimentally-induced acute serum sickness.实验性诱导急性血清病兔肾小球中血小板和多形核中性粒细胞来源的阳离子蛋白定位及阴离子位点局部缺失
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Studies on passive serum sickness. I. The glomerular fine structure of serum sickness nephritis induced by preformed antigen-antibody complexes in the mouse.被动血清病研究。I. 小鼠中预先形成的抗原-抗体复合物诱导的血清病肾炎的肾小球精细结构
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Effect of chemical cationization of antigen on glomerular localization of immune complexes in active models of serum sickness nephritis in rabbits.抗原化学阳离子化对兔血清病肾炎活动模型中免疫复合物肾小球定位的影响。
Immunology. 1986 Aug;58(4):529-34.

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Immunology. 2013 Jul;139(3):328-37. doi: 10.1111/imm.12079.
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Altered distribution of intraglomerular immune complexes in C3-deficient mice.C3 缺陷小鼠肾小球内免疫复合物分布的改变
Immunology. 1999 Jul;97(3):393-9. doi: 10.1046/j.1365-2567.1999.00805.x.
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An acute model for IgA-mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies.一种由单克隆聚合大鼠IgA抗体诱导的大鼠IgA介导的肾小球炎症急性模型。
Clin Exp Immunol. 1993 Jun;92(3):514-21. doi: 10.1111/j.1365-2249.1993.tb03430.x.
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Experimental IgA nephropathy: factors influencing IgA-immune complex deposition in the glomerulus.实验性IgA肾病：影响IgA免疫复合物在肾小球沉积的因素
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Complement-mediated defect in clearance and sequestration of sensitized, autologous erythrocytes in rodent malaria.啮齿动物疟疾中补体介导的致敏自体红细胞清除和隔离缺陷。
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In vivo generation and clearance of soluble immune complexes containing IgM antibodies in normal and decomplemented rabbits.正常及补体缺失兔体内含IgM抗体的可溶性免疫复合物的生成与清除
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Molecular composition of complement-solubilized complexes and their fate in vivo.补体溶解复合物的分子组成及其在体内的命运。
Immunology. 1983 Apr;48(4):779-89.
9
Passively transferred anti-brush border antibodies induce injury of proximal tubules in the absence of complement.被动转移的抗刷状缘抗体在无补体情况下可诱导近端肾小管损伤。
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10
Solubilization of immune complex deposits by native 7S IgG molecules in lupus glomerulonephritis--a possible antigen excess effect on rheumatoid factor-IgG complexes.狼疮性肾小球肾炎中天然7S IgG分子对免疫复合物沉积的溶解作用——类风湿因子-IgG复合物可能存在的抗原过量效应
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Effect of egg passage on the reaction between HVJ (hemagglutinating virus of Japan) and chicken erythrocytes.病毒传代对日本血凝病毒（HVJ）与鸡红细胞之间反应的影响。
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ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.抗原-抗体交叉电泳
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Acute serum sickness nephritis in the rabbit. An immune deposit disease.兔急性血清病肾炎。一种免疫沉积病。
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4
Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them.眼镜蛇毒中的两种抗补体因子：其中一种可使豚鼠红细胞发生溶血。
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Immune complex disease in experimental animals and man.实验动物和人类的免疫复合物疾病。
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Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.备解素在过敏性紫癜和特发性局灶性肾炎中的肾小球沉积。
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补体缺乏的急性血清病兔体内肾结合抗原的延迟清除

Delayed removal of renal-bound antigen in decomplemented rabbits with acute serum sickness.

作者信息

Bartolotti S R, Peters D K

出版信息

Clin Exp Immunol. 1978 May;32(2):199-206.

PMID:352585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541277/
Abstract

We have examined the effects of complement depletion, brought about by cobra venom factor (CVF), on the clearance of radiolabelled BSA from the kidney in acute serum sickness in rabbits. The decomplemented group showed a significant decrease in the rate of clearance of renal-bound antigen with a mean half-clearance time of 19.5 days (range 9.3--60) vs 11.3 (range 8.7--15) for the control group. C3 was rapidly cleared from the glomerulus (as assessed by immunofluorescence) when further deposition was prevented by treatment with CVF. Glomerular immune complexes apparently activated the alternative pathway in vitro. These findings suggest that in immune complex nephritis, the clearance of deposited complexes from the kidney is complement-dependent.

摘要

我们研究了由眼镜蛇毒因子（CVF）引起的补体耗竭对兔急性血清病时肾脏中放射性标记牛血清白蛋白（BSA）清除的影响。补体缺失组肾脏结合抗原的清除率显著降低，平均半清除时间为19.5天（范围9.3 - 60天），而对照组为11.3天（范围8.7 - 15天）。当用CVF治疗阻止进一步沉积时，C3从肾小球快速清除（通过免疫荧光评估）。肾小球免疫复合物在体外明显激活替代途径。这些发现表明，在免疫复合物性肾炎中，肾脏中沉积复合物的清除是补体依赖性的。