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Can we improve immune health by restoring microbial biodiversity?

作者信息

Sinkkonen Aki, Roslund Marja, Skevaki Chrysanthi, Mmbaga Blandina T, Nadeau Kari C, Renz Harald

机构信息

Natural Resources Institute Finland (Luke), Helsinki and Turku, Turku, Finland.

Institute of Laboratory Medicine, member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-University Marburg, Marburg, Germany.

出版信息

Nat Rev Immunol. 2025 May 27. doi: 10.1038/s41577-025-01190-1.

DOI:10.1038/s41577-025-01190-1
PMID:40425820
Abstract
摘要

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本文引用的文献

1
Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine.皮肤接触土壤微生物群体会引起对肺炎球菌疫苗的细胞介导免疫的变化。
Sci Rep. 2024 Aug 10;14(1):18573. doi: 10.1038/s41598-024-68235-8.
2
Urban indoor gardening enhances immune regulation and diversifies skin microbiota - A placebo-controlled double-blinded intervention study.城市室内园艺增强免疫调节并使皮肤微生物组多样化 - 一项安慰剂对照双盲干预研究。
Environ Int. 2024 May;187:108705. doi: 10.1016/j.envint.2024.108705. Epub 2024 Apr 26.
3
Cross-sectional associations of different types of nature exposure with psychotropic, antihypertensive and asthma medication.
不同类型自然暴露与精神药物、降压药和哮喘药物的横断面关联。
Occup Environ Med. 2023 Feb;80(2):111-118. doi: 10.1136/oemed-2022-108491. Epub 2023 Jan 16.
4
Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with cecal microbiota changes.鼻腔内给予鲁氏不动杆菌在哮喘小鼠模型中诱导与盲肠微生物群变化相关的 IL-6 介导的保护作用。
Allergy. 2023 May;78(5):1245-1257. doi: 10.1111/all.15606. Epub 2022 Dec 11.
5
A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children.安慰剂对照双盲试验检验免疫介导疾病的生物多样性假说：环境微生物多样性引起儿童细胞因子变化和 T 调节细胞增加。
Ecotoxicol Environ Saf. 2022 Sep 1;242:113900. doi: 10.1016/j.ecoenv.2022.113900. Epub 2022 Aug 3.
6
Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers.室内绿植墙影响与健康相关的共生皮肤微生物群，并增强免疫调节：一项针对城市上班族的随机试验。
Sci Rep. 2022 Apr 20;12(1):6518. doi: 10.1038/s41598-022-10432-4.
7
Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children.长期的生物多样性干预塑造城市日托儿童中与健康相关的共生微生物群。
Environ Int. 2021 Dec;157:106811. doi: 10.1016/j.envint.2021.106811. Epub 2021 Aug 14.
8
Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes.早期生活环境的土地覆盖会改变 1 型糖尿病的风险。
Diabetes Care. 2021 Jul;44(7):1506-1514. doi: 10.2337/dc20-1719. Epub 2021 May 5.
9
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children.生物多样性干预增强日托儿童的免疫调节和与健康相关的共生菌群。
Sci Adv. 2020 Oct 14;6(42). doi: 10.1126/sciadv.aba2578. Print 2020 Oct.
10
Early life microbial exposures and allergy risks: opportunities for prevention.早期生活中的微生物暴露与过敏风险：预防的机会。
Nat Rev Immunol. 2021 Mar;21(3):177-191. doi: 10.1038/s41577-020-00420-y. Epub 2020 Sep 11.