Ecosystems and Environment Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Niemenkatu 73, 15140, Lahti, Finland.
Natural Resources Institute Finland, Horticulture Technologies, Turku and Helsinki, Finland.
Sci Rep. 2022 Apr 20;12(1):6518. doi: 10.1038/s41598-022-10432-4.
Urbanization reduces microbiological abundance and diversity, which has been associated with immune mediated diseases. Urban greening may be used as a prophylactic method to restore microbiological diversity in cities and among urbanites. This study evaluated the impact of air-circulating green walls on bacterial abundance and diversity on human skin, and on immune responses determined by blood cytokine measurements. Human subjects working in offices in two Finnish cities (Lahti and Tampere) participated in a two-week intervention, where green walls were installed in the rooms of the experimental group. Control group worked without green walls. Skin and blood samples were collected before (Day0), during (Day14) and two weeks after (Day28) the intervention. The relative abundance of genus Lactobacillus and the Shannon diversity of phylum Proteobacteria and class Gammaproteobacteria increased in the experimental group. Proteobacterial diversity was connected to the lower proinflammatory cytokine IL-17A level among participants in Lahti. In addition, the change in TGF-β1 levels was opposite between the experimental and control group. As skin Lactobacillus and the diversity of Proteobacteria and Gammaproteobacteria are considered advantageous for skin health, air-circulating green walls may induce beneficial changes in a human microbiome. The immunomodulatory potential of air-circulating green walls deserves further research attention.
城市化降低了微生物的丰度和多样性，这与免疫介导的疾病有关。城市绿化可以作为一种预防措施，在城市和城市居民中恢复微生物多样性。本研究评估了空气流通绿墙对人体皮肤细菌丰度和多样性以及通过血液细胞因子测量确定的免疫反应的影响。在芬兰的两个城市（拉赫蒂和坦佩雷）工作的人类受试者参与了为期两周的干预，实验组的房间安装了绿墙。对照组在没有绿墙的情况下工作。在干预前（第 0 天）、期间（第 14 天）和干预后两周（第 28 天）采集皮肤和血液样本。属乳酸杆菌的相对丰度和门变形菌纲和纲γ变形菌纲的香农多样性在实验组中增加。在拉赫蒂的参与者中，变形菌多样性与较低的促炎细胞因子 IL-17A 水平有关。此外，实验组和对照组之间 TGF-β1 水平的变化相反。由于皮肤乳酸杆菌和变形菌纲以及γ变形菌纲的多样性被认为对皮肤健康有益，空气流通绿墙可能会诱导人体微生物组的有益变化。空气流通绿墙的免疫调节潜力值得进一步研究关注。
