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胰胆管交界处变异的患病率及其与癌症关联的系统评价和荟萃分析

A Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer.

作者信息

Valenzuela-Fuenzalida Juan José, Beas-Gambi Antonia, Matta-Leiva Josefa, Martínez-Hernández Daniela, Milos Daniel, Orellana-Donoso Mathias, Santibáñez Alejandra Suazo, Bruna-Mejias Alejandro, Riveros Andres Sebastian, Becerra-Farfan Alvaro, Sanchis-Gimeno Juan, Gutierrez-Espinoza Héctor, Bastidas-Caldes Carlos

机构信息

Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago 8370321, Chile.

Escuela de Medicina, Universidad Finis Terrae, Santiago 7501015, Chile.

出版信息

Biomedicines. 2025 Apr 25;13(5):1039. doi: 10.3390/biomedicines13051039.

DOI:10.3390/biomedicines13051039
PMID:40426867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12109207/
Abstract

The objective of this study was to describe the anatomical variants of the pancreaticobiliary junction and how its position or structural change could be associated with hepatic, duodenal, and pancreatic clinical complications. We searched MEDLINE, Scopus, Web of Science (WOS), Google Scholar, CINAHL, and EMBASE databases from their inception up to September 2024. Two authors independently performed the search, study selection, data extraction, and assessed the methodological quality with an assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. A total of 59 studies with a total of 22,752 participants were included in this review. The overall prevalence of the anomalous pancreaticobiliary junction (APBJ) variant was 12% (95% CI = 6% to 18%). The prevalence of cancer associated with variants of APBJ was 29% (95% CI = 23% to 34%). In the present anatomical systematic review and meta-analysis, we found that a longer common channel correlated with a higher prevalence of bile duct or gallbladder malignancy, due to the backward flow of bile which occurs as a result of the position and distance of the bile ducts, as well as pancreatic failing. Hence, APBJs are of great interest for gastroduodenal surgeons.

摘要

本研究的目的是描述胰胆管交界处的解剖变异，以及其位置或结构变化如何与肝脏、十二指肠和胰腺的临床并发症相关。我们检索了MEDLINE、Scopus、科学网（WOS）、谷歌学术、护理学与健康领域数据库（CINAHL）和EMBASE数据库，检索时间从各数据库建库起至2024年9月。两位作者独立进行检索、研究筛选、数据提取，并使用解剖学研究保证工具（AQUA）评估方法学质量。最后，使用随机效应模型估计合并患病率。本综述共纳入59项研究，总计22,752名参与者。胰胆管连接异常（APBJ）变异的总体患病率为12%（95%置信区间=6%至18%）。与APBJ变异相关的癌症患病率为29%（95%置信区间=23%至34%）。在本次解剖学系统评价和荟萃分析中，我们发现，由于胆管的位置和距离以及胰腺功能障碍导致胆汁逆流，较长的共同通道与胆管或胆囊恶性肿瘤的较高患病率相关。因此，APBJ对胃十二指肠外科医生具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/8e2b006eb08d/biomedicines-13-01039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/fb773ee3f223/biomedicines-13-01039-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/8e2b006eb08d/biomedicines-13-01039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/fb773ee3f223/biomedicines-13-01039-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/ee9f5c072eef/biomedicines-13-01039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/954288d13611/biomedicines-13-01039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/de1648975594/biomedicines-13-01039-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/4b89cc468f4d/biomedicines-13-01039-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/10557978389a/biomedicines-13-01039-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d11/12109207/8e2b006eb08d/biomedicines-13-01039-g009.jpg

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本文引用的文献

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2
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.PRISMA 2020 声明：系统评价报告的更新指南。
BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
3
Anomalous Pancreaticobiliary Duct Junction in an Unusual Case of Synchronous Gallbladder and Bile Duct Malignancy.
同步发生胆囊和胆管恶性肿瘤的罕见病例中的异常胰胆管连接
Cureus. 2021 Feb 13;13(2):e13331. doi: 10.7759/cureus.13331.
4
Risk factors and characteristics of young patients with the biliary tract carcinoma: results of a project study for biliary surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.胆道癌青年患者的危险因素和特征：日本肝胆胰外科学会胆道外科项目研究的结果。
J Hepatobiliary Pancreat Sci. 2020 Sep;27(9):571-580. doi: 10.1002/jhbp.776. Epub 2020 Jul 30.
5
Imaging of Pancreaticobiliary Maljunction.胰胆管合流异常的影像学表现。
Radiographics. 2020 Mar-Apr;40(2):378-392. doi: 10.1148/rg.2020190108. Epub 2020 Jan 17.
6
IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction.胆囊癌中 IL-33 的过表达与胰胆管合流异常相关。
Histopathology. 2019 Sep;75(3):365-375. doi: 10.1111/his.13863. Epub 2019 Jul 2.
7
Redeveloping the JBI Model of Evidence Based Healthcare.重新开发 JBI 循证医疗保健模式。
Int J Evid Based Healthc. 2018 Dec;16(4):227-241. doi: 10.1097/XEB.0000000000000139.
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9
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