Department of Ophthalmology, Kangwon National University School of Medicine, Chuncheon, Korea.
Department of Ophthalmology, Kangwon National University Hospital, Chuncheon, Korea.
Medicine (Baltimore). 2023 Oct 6;102(40):e35354. doi: 10.1097/MD.0000000000035354.
Optical coherence tomography (OCT) can detect visual alterations associated with Parkinson disease, such as damage to the retinal nerve fiber layer or changes in retinal vasculature. Macula thinning in association with Parkinson disease (PD) remains controversial. Therefore, we conducted a meta-analysis to investigate the central retina thickness in PD measured using spectral-domain OCT (SD-OCT).
We searched PubMed and the Excerpta Medica database to identify studies that compared macular thickness between patients with PD and healthy controls published before July 31, 2021. A random-effects model was used to examine PD-associated changes in macular thickness. Meta-regression analysis was performed by assessing heterogeneity, publication bias, and study quality.
Thirty-two studies with a cross-sectional design were selected, including 2118 patients with PD and 2338 controls. We identified significant differences in the thickness of the ganglion cell-inner plexiform layer (standardized mean difference [SMD], -0.41; 95% confidence interval [CI], -0.66 to -0.16; I2 = 80%), ganglion cell complex (SMD, -0.33; 95% CI, -0.50 to -0.17; I2 = 0%), and of all inner and outer sectors of the macula (SMD range, -0.21 to -0.56; all P < .05) between patients with PD and controls.
These results corroborate the increased prevalence of changes in OCT measures in individuals with PD, highlighting the efficacy of SD-OCT-determined macular thickness as a biomarker for PD. Our findings may provide helpful guidelines for clinicians in rapidly evolving areas of PD diagnosis.
光学相干断层扫描（OCT）可检测与帕金森病相关的视觉改变，例如视网膜神经纤维层损伤或视网膜血管变化。与帕金森病（PD）相关的黄斑变薄仍然存在争议。因此，我们进行了一项荟萃分析，以研究使用谱域 OCT（SD-OCT）测量的 PD 患者的中心视网膜厚度。
我们检索了 PubMed 和 Excerpta Medica 数据库，以确定 2021 年 7 月 31 日前发表的比较 PD 患者和健康对照者黄斑厚度的研究。使用随机效应模型检查 PD 相关的黄斑厚度变化。通过评估异质性、发表偏倚和研究质量进行元回归分析。
选择了 32 项横断面设计的研究，包括 2118 名 PD 患者和 2338 名对照者。我们发现，在神经节细胞-内丛状层（标准化均数差 [SMD]，-0.41；95%置信区间 [CI]，-0.66 至 -0.16；I² = 80%）、神经节细胞复合体（SMD，-0.33；95%CI，-0.50 至 -0.17；I² = 0%）和所有内、外黄斑区（SMD 范围，-0.21 至 -0.56；均 P <.05）的厚度方面，PD 患者与对照组存在显著差异。
这些结果证实了 PD 患者的 OCT 测量值改变的发生率增加，突出了 SD-OCT 确定的黄斑厚度作为 PD 生物标志物的有效性。我们的研究结果可能为 PD 诊断等快速发展领域的临床医生提供有价值的指导。
