Yardim Meltem, Deniz Levent, Saltabas Mehmet Akif, Celik Nilufer
Department of Medical Biochemistry, Yerkoy State Hospital, 66900 Yozgat, Türkiye.
Department of Medical Biochemistry, University of Health Sciences, Istanbul Training and Research Hospital, 34098 Istanbul, Türkiye.
Diagnostics (Basel). 2025 May 14;15(10):1248. doi: 10.3390/diagnostics15101248.
This study aimed to investigate the effects of thyroxine replacement therapy (TRT) on serum Maresin 1 and nuclear factor kappa beta (NF-kB) levels in patients with Hashimoto's thyroiditis (HT). A total of 90 patients were included in this study, 60 with HT and 30 without. Patients in the HT group were divided into two groups according to whether they received TRT. Group 1 included 30 patients who underwent TRT, and Group 2 comprised 30 patients who were newly diagnosed with HT, either euthyroid or hypothyroid. The analysis included serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody (TPOAb), Maresin 1, and NF-kB. The serum NF-kB level in the TRT group was significantly higher than that in the control and non-TRT groups. In the subgroup analysis of patients who did not receive TRT, the serum NF-kB level in euthyroid patients was significantly lower than that in hypothyroid patients. Maresin 1 levels in the control group were significantly higher than those in patients who did and did not receive TRT. The serum Maresin 1 level in the TRT group was significantly lower than that in the untreated group. Maresin 1 levels were higher in the euthyroid group than in the hypothyroid group. TPOAb levels were positively correlated with NF-kB and negatively correlated with Maresin 1. TRT maintains the euthyroid state in patients with HT, but may not contribute positively to the pro-anti-inflammatory balance in these patients.
本研究旨在探讨甲状腺素替代疗法（TRT）对桥本甲状腺炎（HT）患者血清玛瑞辛1和核因子κB（NF-κB）水平的影响。本研究共纳入90例患者，其中60例为HT患者，30例为非HT患者。HT组患者根据是否接受TRT分为两组。第1组包括30例接受TRT的患者，第2组包括30例新诊断为HT的患者，包括甲状腺功能正常或甲状腺功能减退患者。分析指标包括血清促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、甲状腺过氧化物酶抗体（TPOAb）、玛瑞辛1和NF-κB。TRT组的血清NF-κB水平显著高于对照组和未接受TRT组。在未接受TRT患者的亚组分析中，甲状腺功能正常患者的血清NF-κB水平显著低于甲状腺功能减退患者。对照组的玛瑞辛1水平显著高于接受和未接受TRT的患者。TRT组的血清玛瑞辛1水平显著低于未治疗组。甲状腺功能正常组的玛瑞辛1水平高于甲状腺功能减退组。TPOAb水平与NF-κB呈正相关，与玛瑞辛1呈负相关。TRT可维持HT患者的甲状腺功能正常状态，但可能对这些患者的促炎-抗炎平衡没有积极作用。
