Sun Hao, Li Jiao, Zhao Changhui, Ren Chunming, Tian Tian, Lei Chong, Sun Xuecheng
Microelectronics Research & Development Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
National Key Laboratory of Advanced Micro and Nano Manufacture Technology, Department of Micro-Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China.
Micromachines (Basel). 2025 May 3;16(5):559. doi: 10.3390/mi16050559.
Magnetic biosensors have wide applications in biological target detection due to their advantages such as low background noise, convenient detection, and low requirements for sample pretreatment. However, existing magnetic biosensors still have the drawback of low sensitivity compared to optical and electrochemical biosensors. This paper presents the novel design of a high-sensitivity magnetic biosensor by utilizing the magnetic field line convergence effect, which was applied to bacterial detection. The results indicate that it can achieve a detection limitation of 10 CFU/mL, demonstrating that it can be implemented in high-sensitivity biological target detection.
磁生物传感器因其背景噪声低、检测方便、对样品预处理要求低等优点，在生物靶标检测中具有广泛应用。然而，与光学和电化学生物传感器相比，现有的磁生物传感器仍存在灵敏度低的缺点。本文利用磁力线汇聚效应提出了一种高灵敏度磁生物传感器的新颖设计，并将其应用于细菌检测。结果表明，该传感器的检测限可达10 CFU/mL，证明其可用于高灵敏度生物靶标检测。
