Bonis Angela De, Curcio Mariangela, Galasso Agostino, Caggiano Nicola, Lettino Antonio, Dolce Patrizia, Mollica Donato, Pace Maria Lucia, Santagata Antonio
Dipartimento di Scienze di Base e Applicate, Università Degli Studi Della Basilicata, Viale Dell'ateneo Lucano 10, 85100 Potenza, Italy.
Dipartimento di Chimica, Università Degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy.
Materials (Basel). 2025 May 19;18(10):2362. doi: 10.3390/ma18102362.
Laser nanostructuring via Laser-Induced Periodic Surface Structures (LIPSS), generated using femtosecond laser pulses, has been investigated as a method for precisely modifying titanium surfaces. By adjusting parameters such as the fluence and pulse number of the laser beam, it is feasible to tailor the surface morphology, roughness, and oxidation states of species that can significantly influence the properties and surface bioactivity of the material. In this study, the LIPSS was applied to commercially pure titanium and evaluated for its ability to support calcium phosphate nucleation and growth in Simulated Body Fluid (SBF). Scanning Electron Microscopy (SEM) and Fast Fourier Transform (FFT) analysis confirmed the formation of well-defined periodic structures. Additional characterizations performed by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS) revealed, after laser treatment of titanium, its increased surface roughness and oxidation levels, respectively. These features, when assessed after immersion in SBF, were associated with an improved potential biological performance of the nanostructured surface of the investigated material. The results demonstrated that LIPSS-treated titanium effectively promoted calcium phosphate growth, indicating its enhanced potential bioactivity. Overall, LIPSS nanostructuring presents a scalable and cost-effective strategy for engineering titanium surfaces with potential bioactive properties, supporting their promising application in advanced biomedical implants.
通过飞秒激光脉冲产生的激光诱导周期性表面结构（LIPSS）进行激光纳米结构化，已被研究作为一种精确修饰钛表面的方法。通过调整激光束的能量密度和脉冲数等参数，可以定制能够显著影响材料性能和表面生物活性的物种的表面形态、粗糙度和氧化态。在本研究中，LIPSS应用于商业纯钛，并评估其在模拟体液（SBF）中支持磷酸钙成核和生长的能力。扫描电子显微镜（SEM）和快速傅里叶变换（FFT）分析证实了明确的周期性结构的形成。通过原子力显微镜（AFM）和X射线光电子能谱（XPS）进行的额外表征分别显示，钛经过激光处理后，其表面粗糙度和氧化水平增加。在浸入SBF后评估时，这些特征与所研究材料的纳米结构表面改善的潜在生物学性能相关。结果表明，LIPSS处理的钛有效地促进了磷酸钙的生长，表明其增强的潜在生物活性。总体而言，LIPSS纳米结构化提出了一种可扩展且具有成本效益的策略，用于设计具有潜在生物活性特性的钛表面，支持它们在先进生物医学植入物中的有前景的应用。
