Kowalczyk Adam, Tuberoso Carlo Ignazio Giovanni, Jerković Igor
Department of Pharmacognosy and Herbal Medicines, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Antioxidants (Basel). 2024 Oct 28;13(11):1313. doi: 10.3390/antiox13111313.
Rosmarinic acid (RA), a polyphenolic compound found in herbs, such as rosemary, basil, and mint, has garnered significant attention due to its potent antioxidant and anticancer properties. This review examined the molecular mechanisms underlying these properties and their potential application in cancer prevention and therapy. It focuses specifically on RA's role in modulating cancer-related pathways and presents a detailed analysis of recent advancements in this area. A systematic review of PubMed, Scopus, and Web of Science databases was conducted in accordance with PRISMA (Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, focusing on studies published between 2019 and 2024. A total of 25 articles providing evidence from in vitro, in vivo, and in silico studies were selected. These findings elucidate the role of RA in inhibiting tumor cell proliferation, inducing apoptosis, and preventing metastasis in various types of cancer through diverse mechanisms, including its antioxidant properties. Despite these promising results, RA's bioavailability challenges limit its therapeutic efficacy, underscoring the necessity for improved delivery methods. This review concludes that RA exhibits significant potential as a natural agent for cancer prevention and treatment, although further clinical trials are warranted.
迷迭香酸（RA）是一种存在于迷迭香、罗勒和薄荷等草药中的多酚化合物，因其强大的抗氧化和抗癌特性而备受关注。本综述研究了这些特性背后的分子机制及其在癌症预防和治疗中的潜在应用。它特别关注RA在调节癌症相关途径中的作用，并对该领域的最新进展进行了详细分析。根据PRISMA（系统评价和Meta分析报告项目）指南，对PubMed、Scopus和Web of Science数据库进行了系统评价，重点关注2019年至2024年发表的研究。共筛选出25篇提供体外、体内和计算机模拟研究证据的文章。这些发现阐明了RA通过多种机制（包括其抗氧化特性）在抑制各种类型癌症的肿瘤细胞增殖、诱导凋亡和预防转移方面的作用。尽管取得了这些令人鼓舞的结果，但RA的生物利用度挑战限制了其治疗效果，凸显了改进给药方法的必要性。本综述得出结论，RA作为一种天然的癌症预防和治疗药物具有巨大潜力，不过仍需进一步开展临床试验。
