Tudoroiu Elena-Emilia, Albu Kaya Mădălina Georgiana, Dinu-Pîrvu Cristina Elena, Popa Lăcrămioara, Anuța Valentina, Ignat Mădălina, Visileanu Emilia, Kaya Durmuș Alpaslan, Prisada Răzvan Mihai, Ghica Mihaela Violeta
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.
Innovative Therapeutic Structures Research and Development Center (InnoTher), "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania.
Pharmaceuticals (Basel). 2025 May 7;18(5):689. doi: 10.3390/ph18050689.
: Developing versatile dressings that offer wound protection, maintain a moist environment, and facilitate healing represents an important therapeutic approach for burn patients. : This study presents the development of new smart pH-sensitive collagen-hydroxyethylcellulose films, incorporating naproxen and phenol red, designed to provide controlled drug release while enabling real-time pH monitoring for burn care. : Biopolymeric films were prepared by the solvent-casting method using ethanol and glycerol as plasticizers. : Orange-colored films were thin, flexible, and easily peelable, with uniform, smooth, and nonporous morphology. Tensile strength varied from 0.61 N/mm to 3.33 N/mm, indicating improved mechanical properties with increasing collagen content, while wetting analysis indicated a hydrophilic surface with contact angle values between 17.61° and 75.51°. Maximum swelling occurred at pH 7.4, ranging from 5.65 g/g to 9.20 g/g and pH 8.5, with values from 4.74 g/g to 7.92 g/g, suggesting effective exudate absorption. In vitro degradation proved structural stability maintenance for at least one day, with more than 40% weight loss. Films presented a biphasic naproxen release profile with more than 75% of the drug released after 24 h, properly managing inflammation and pain on the first-day post-burn. The pH variation mimicking the stages of the healing process demonstrated the color transition from yellow (pH 5.5) to orange (pH 7.4) and finally to bright fuchsia (pH 8.5), enabling easy visual evaluation of the wound environment. : New multifunctional films combine diagnostic and therapeutic functions, providing a promising platform for monitoring wound healing, making them suitable for real-time wound assessment.
开发具有伤口保护功能、能维持湿润环境并促进愈合的多功能敷料，是烧伤患者重要的治疗方法。本研究展示了新型智能pH敏感型胶原 - 羟乙基纤维素薄膜的研发，该薄膜含有萘普生和酚红，旨在实现药物的控释，同时能够对烧伤护理进行实时pH监测。通过溶剂浇铸法制备生物聚合物薄膜，使用乙醇和甘油作为增塑剂。橙色薄膜薄而柔韧，易于剥离，具有均匀、光滑且无孔的形态。拉伸强度在0.61 N/mm至3.33 N/mm之间变化，表明随着胶原含量的增加机械性能得到改善，而润湿性分析表明其表面具有亲水性，接触角值在17.61°至75.51°之间。最大溶胀发生在pH 7.4时，范围为5.65 g/g至9.20 g/g，以及pH 8.5时，值为4.74 g/g至7.92 g/g，表明具有有效的渗出液吸收能力。体外降解证明至少一天内结构稳定性得以维持，重量损失超过40%。薄膜呈现双相萘普生释放曲线，24小时后超过75%的药物释放，能有效控制烧伤后第一天的炎症和疼痛。模拟愈合过程阶段的pH变化表明颜色从黄色（pH 5.5）转变为橙色（pH 7.4），最终变为亮紫红色（pH 8.5），便于直观评估伤口环境。新型多功能薄膜结合了诊断和治疗功能，为监测伤口愈合提供了一个有前景的平台，使其适用于实时伤口评估。
