Chen Junwei, Gou Zhonglang, Huang Yufei, Yu Qianhui, Kim An Na, Shi Wenchao, Zhou You
State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.
Westa College, Southwest University, Chongqing 400715, China.
Pharmaceuticals (Basel). 2025 May 8;18(5):695. doi: 10.3390/ph18050695.
With the intensification of the population aging worldwide, neurological disorders (NDs) are seriously threatening human society. Mulberry, a traditional economic crop, is a significant medicinal plant. Increasing evidence suggests that phytochemicals from mulberry play critical roles in the prevention and treatment of NDs. This paper reviews the recently reported phytochemicals from mulberry with neuroprotective effects and systematically summarizes neuroprotective mechanisms and their classifications. Based on their origins from different parts of mulberry, the extracts with neuroprotective effects are classified into mulberry fruit extract and mulberry leaf extract. According to the compound structures, the compounds are divided into flavonoids, Diels-Alder-type adducts (DAAs), benzofurans, quinones, stilbenes, and alkaloids. This aims to provide a future reference for their pharmaceutical development and utilization.
随着全球人口老龄化的加剧，神经疾病严重威胁着人类社会。桑树作为一种传统经济作物，是一种重要的药用植物。越来越多的证据表明，桑树中的植物化学物质在神经疾病的预防和治疗中发挥着关键作用。本文综述了最近报道的具有神经保护作用的桑树植物化学物质，并系统总结了其神经保护机制及其分类。根据其来源于桑树的不同部位，具有神经保护作用的提取物分为桑椹果提取物和桑叶提取物。根据化合物结构，这些化合物分为黄酮类、狄尔斯-阿尔德型加合物（DAAs）、苯并呋喃类、醌类、芪类和生物碱类。这旨在为它们的药物开发和利用提供未来参考。
