Hoeprich P D, Merry J M
Eur J Clin Microbiol. 1985 Aug;4(4):400-3. doi: 10.1007/BF02148692.
The activity of two new antifungal azoles, BAY n 7133 and BAY 1 9139, against Coccidioides immitis was compared with that of ketoconazole in vitro and in experimental murine coccidioidomycosis. Daily intravenous injections were given for 30 days. All mice were autopsied and suspensions of lung, liver and spleen cultured. BAY n 7133 was as active as ketoconazole while Bay 1 9139 was les active. All three drugs were coccidioidostatic only both in vitro and in vivo.
在体外实验和实验性小鼠球孢子菌病模型中，比较了两种新型抗真菌唑类药物BAY n 7133和BAY 1 9139对粗球孢子菌的活性与酮康唑的活性。每日静脉注射给药30天。所有小鼠均进行解剖，并对肺、肝和脾的悬液进行培养。BAY n 7133的活性与酮康唑相当，而BAY 1 9139的活性较低。这三种药物在体外和体内均仅具有抑制球孢子菌生长的作用。
