Maya-Badillo Brenda Aline, Orta-Pineda Guillermo, Suzán Gerardo, Rivera-Rosas Karen Elizabeth, Zavala-Vasco Diego, Uribe-Jacinto Adrián, Chaves Andrea, Grande-Cano Alfredo, Segura-Velazquez René, Sánchez-Betancourt José Iván
Laboratorio de Ecología de Enfermedades y Una Salud del Departamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.
Laboratorio de Investigación del Departamento de Medicina y Zootecnia de Cerdos, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.
Pathogens. 2025 Apr 25;14(5):414. doi: 10.3390/pathogens14050414.
With the first evidence of the association between bats and influenza A viruses, various studies have begun to emerge to understand this interesting and important association among bats conservation, animal health, and public health. This study aimed to verify the presence of anti-influenza A vipothesrus antibodies, as well as the molecular identification of these viruses in bats distributed in forest fragments located in southeastern Mexico. Blood samples were obtained from 600 bats belonging to 24 different species, using an enzyme immunoassay to detect antibodies against the nucleoprotein antigen of the avian influenza A virus. Likewise, oropharyngeal swabs, rectal swabs and organs were taken for quantitative reverse transcription PCR (qRT-PCR) of these viruses. A total of six bats (1%) tested positive either by serology or molecular methods, not both simultaneously. Although this suggests a very low prevalence of influenza A viruses in Mexican bats, it is the first study to address this association and, following the precautionary principle, we consider it necessary to establish systematic monitoring of the presence of influenza A in bats, since they are known to harbor infectious agents with zoonotic potential. Furthermore, it is possible that the association of influenza A viruses circulating in Latin American bats has an important co-evolutionary component with some bat species with exclusive distribution in the American continent.
随着蝙蝠与甲型流感病毒之间关联的首个证据出现，各种研究开始涌现，以了解蝙蝠保护、动物健康和公共卫生之间这种有趣且重要的关联。本研究旨在验证墨西哥东南部森林碎片中分布的蝙蝠体内抗甲型流感病毒抗体的存在情况，以及对这些病毒进行分子鉴定。从属于24个不同物种的600只蝙蝠身上采集血样，采用酶免疫测定法检测针对甲型禽流感病毒核蛋白抗原的抗体。同样，采集口咽拭子、直肠拭子和器官用于这些病毒的定量逆转录聚合酶链反应（qRT-PCR）。共有6只蝙蝠（1%）通过血清学或分子方法检测呈阳性，但并非同时通过两种方法检测呈阳性。尽管这表明墨西哥蝙蝠中甲型流感病毒的流行率非常低，但这是第一项针对这种关联的研究，根据预防原则，我们认为有必要对蝙蝠中甲型流感病毒的存在情况进行系统监测，因为已知它们携带具有人畜共患病潜力的传染源。此外，在拉丁美洲蝙蝠中传播的甲型流感病毒与一些仅分布在美洲大陆的蝙蝠物种之间的关联可能具有重要的共同进化成分。
