Paniagua-García Ana I, Ibáñez Ana, Díez-Antolínez Rebeca
Centro de I+D de Biocombustibles y Bioproductos del Instituto Tecnológico Agrario de Castilla y León (ITACyL), Villarejo de Órbigo, 24358 Leon, Spain.
Instituto Tecnológico Agrario de Castilla y León (ITACyL), Área de Investigación Agrícola, 47071 Valladolid, Spain.
Pathogens. 2025 Apr 25;14(5):418. doi: 10.3390/pathogens14050418.
Natural compounds represent a fundamental source of antimicrobial agents with applications in numerous industries. This study investigates the antimicrobial properties of different fractions of extracts obtained from six hop varieties, as well as of certain compounds contained in hops and other plants. The results indicate that soft resins exhibit the strongest antibacterial activity among the hop-derived fractions evaluated, reaching a minimum MIC value of 25 µg/mL (Fuggle variety) against Gram-positive bacteria () and 50 µg/mL (Chinook variety) against Gram-negative bacteria (). Furthermore, the composition of hops varies among varieties, resulting in divergent antimicrobial patterns, indicating the necessity for further research to elucidate the origins of these activities. Additionally, while hop-derived fractions exhibited noteworthy antibacterial properties, their antifungal activity against was found to be negligible. In addition, natural compounds such as carvacrol and thymol demonstrated the lowest MIC values against (130 and 250 µg/mL, respectively) and (280 and 250 µg/mL, respectively). Moreover, xanthohumol exhibited a better MIC value against (3 µg/mL), while no inhibitory effects were observed against . These insights highlight the necessity for further exploration of natural extracts in the development of new antimicrobial agents.
天然化合物是抗菌剂的重要来源，在众多行业中都有应用。本研究调查了从六个啤酒花品种中提取的不同馏分以及啤酒花和其他植物中所含某些化合物的抗菌特性。结果表明，在所评估的啤酒花衍生馏分中，软树脂表现出最强的抗菌活性，对革兰氏阳性菌（法格品种）的最低 MIC 值达到 25 µg/mL，对革兰氏阴性菌（奇努克品种）的最低 MIC 值为 50 µg/mL。此外，不同品种的啤酒花成分不同，导致抗菌模式各异，这表明有必要进一步研究以阐明这些活性的来源。此外，虽然啤酒花衍生馏分表现出显著的抗菌特性，但发现它们对[某种真菌]的抗真菌活性可忽略不计。此外，香芹酚和百里香酚等天然化合物对[某种细菌]的 MIC 值最低（分别为 130 和 250 µg/mL）以及对[另一种细菌]的 MIC 值最低（分别为 280 和 250 µg/mL）。此外，黄腐酚对[某种真菌]表现出较好的 MIC 值（3 µg/mL），而对[另一种真菌]未观察到抑制作用。这些见解凸显了在开发新型抗菌剂方面进一步探索天然提取物的必要性。
