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镁的摄入量或血液水平与代谢综合征风险：观察性研究的荟萃分析

Intake or Blood Levels of Magnesium and Risk of Metabolic Syndrome: A Meta-Analysis of Observational Studies.

作者信息

Kim Youngyo, Je Youjin

机构信息

Department of Food and Nutrition/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.

Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea.

出版信息

Nutrients. 2025 May 14;17(10):1667. doi: 10.3390/nu17101667.

DOI:10.3390/nu17101667
PMID:40431407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12113937/
Abstract

BACKGROUND/OBJECTIVES: The association between magnesium and metabolic syndrome has not been comprehensively examined. We conducted a meta-analysis to quantitatively evaluate the association between intake and blood levels of magnesium and metabolic syndrome.

METHODS

We searched PubMed, Scopus, and ISI Web of Science databases to identify studies reporting an association between magnesium and metabolic syndrome up to April 2025. To pool the effect sizes on metabolic syndrome according to intake and blood levels of magnesium, a random effects model was used.

RESULTS

Twenty-seven publications including 95,933 participants were included in the meta-analysis. The relative risk summary of metabolic syndrome for highest versus lowest intake of magnesium was 0.79 (95% confidence interval [CI]: 0.71-0.88) for prospective cohort studies. In the meta-analysis of cross-sectional studies, magnesium intake was inversely associated with metabolic syndrome (odds ratio = 0.61; 95% CI: 0.39-0.94). High blood levels of magnesium were inversely associated with metabolic syndrome (effect estimate = 0.53; 95% CI: 0.37-0.76).

CONCLUSIONS

The present meta-analysis indicated that magnesium intake was inversely associated with a risk of metabolic syndrome. Regarding the association between blood levels of magnesium and metabolic syndrome, a significant inverse association was found, but the interpretation was cautious due to the observed high heterogeneity. The association between magnesium status and metabolic syndrome needs to be confirmed with further prospective studies.

摘要

背景/目的：镁与代谢综合征之间的关联尚未得到全面研究。我们进行了一项荟萃分析，以定量评估镁的摄入量和血液水平与代谢综合征之间的关联。

方法

我们检索了PubMed、Scopus和ISI Web of Science数据库，以识别截至2025年4月报告镁与代谢综合征之间关联的研究。为了汇总根据镁的摄入量和血液水平对代谢综合征的效应量，使用了随机效应模型。

结果

荟萃分析纳入了27篇出版物，共95933名参与者。前瞻性队列研究中，镁摄入量最高与最低者相比，代谢综合征的相对风险汇总值为0.79（95%置信区间[CI]：0.71 - 0.88）。在横断面研究的荟萃分析中，镁摄入量与代谢综合征呈负相关（优势比 = 0.61；95% CI：0.39 - 0.94）。高血液镁水平与代谢综合征呈负相关（效应估计值 = 0.53；95% CI：0.37 - 0.76）。

结论

本荟萃分析表明，镁摄入量与代谢综合征风险呈负相关。关于血液镁水平与代谢综合征之间的关联，发现了显著的负相关，但由于观察到的高度异质性，解释时需谨慎。镁状态与代谢综合征之间的关联需要进一步的前瞻性研究来证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/c0c481bf9cba/nutrients-17-01667-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/229e05b05f5b/nutrients-17-01667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/f7cf149542d3/nutrients-17-01667-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/516e7a720fc8/nutrients-17-01667-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/c0c481bf9cba/nutrients-17-01667-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/229e05b05f5b/nutrients-17-01667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/f7cf149542d3/nutrients-17-01667-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/516e7a720fc8/nutrients-17-01667-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41de/12113937/c0c481bf9cba/nutrients-17-01667-g004.jpg

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