Jacobs N F, Kraus S J, Thornsberry C, Bullard J
J Clin Microbiol. 1977 Mar;5(3):365-9. doi: 10.1128/jcm.5.3.365-369.1977.
A new colony type of Neisseria gonorrhoeae was detected in the primary cultures from 8 of 180 men with gonococcal urethritis. This colony type contrasts with those previously described by having a rough and irregular surface. In six of the eight cases, the rough form predominated. The distinctive morphology of the rough colony variant could be maintained indefinitely by selective subculture. By electron microscopy, organisms taken from rough colonies of each of the eight isolates were piliated. Antimicrobial susceptibilities of type 1 and rough clones derived from the same patients were identical for ampicillin, penicillin, tetracycline, and spectinomycin. After inoculation of rough colonies into subcutaneous chambers in mice and guinea pigs, type 1 colonies predominated in cultures of material obtained from the chambers. This new piliated colony type of N. gonorrhoeae may provide an opportunity to investigate factors other than pili that contribute to gonococcal virulence.
在180例淋菌性尿道炎男性患者的初代培养物中，检测到一种新型淋病奈瑟菌菌落类型。这种菌落类型与先前描述的不同，其表面粗糙且不规则。在8例中的6例中，粗糙型占主导。通过选择性传代培养，粗糙菌落变体的独特形态可无限期保持。通过电子显微镜观察，从8株分离株的粗糙菌落中获取的菌体都有菌毛。来自同一患者的1型和粗糙克隆株对氨苄西林、青霉素、四环素和壮观霉素的药敏性相同。将粗糙菌落接种到小鼠和豚鼠的皮下腔室后，从腔室获取的培养物中1型菌落占主导。这种新型有菌毛的淋病奈瑟菌菌落类型可能为研究除菌毛外其他有助于淋球菌毒力的因素提供机会。
